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Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of memb...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society for Pediatric Endocrinology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981048/ https://www.ncbi.nlm.nih.gov/pubmed/35431443 http://dx.doi.org/10.1297/cpe.2021-0061 |
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author | Tominaga, Takahiro Ikeda, Kazushige Awazu, Midori |
author_facet | Tominaga, Takahiro Ikeda, Kazushige Awazu, Midori |
author_sort | Tominaga, Takahiro |
collection | PubMed |
description | Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of membranes for 32 days, and the patient was delivered at 33 weeks gestation. The cord blood showed ionized calcium 1.54 mmol/L. His serum calcium and magnesium were 11.4 mg/dL and 3.5 mg/dL after birth and fell to 6.6 mg/dL and 2.7 mg/dL at 6 hours, respectively. The intact parathyroid hormone level was 18 pg/mL at 6 h. Radiography showed transverse radiolucent metaphyseal bands of the proximal humerus bone, suggesting disturbance in normal ossification. Transient hypercalcemia before the development of hypocalcemia after maternal magnesium sulfate therapy has not been previously reported. We speculate that maternal long-term magnesium sulfate therapy led to defective ossification and transient hypercalcemia in the offspring. Subsequent hypocalcemia was thought to be due to the inhibition of parathyroid hormone secretion by hypercalcemia and hypermagnesemia. |
format | Online Article Text |
id | pubmed-8981048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society for Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-89810482022-04-15 Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy Tominaga, Takahiro Ikeda, Kazushige Awazu, Midori Clin Pediatr Endocrinol Case Report Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of membranes for 32 days, and the patient was delivered at 33 weeks gestation. The cord blood showed ionized calcium 1.54 mmol/L. His serum calcium and magnesium were 11.4 mg/dL and 3.5 mg/dL after birth and fell to 6.6 mg/dL and 2.7 mg/dL at 6 hours, respectively. The intact parathyroid hormone level was 18 pg/mL at 6 h. Radiography showed transverse radiolucent metaphyseal bands of the proximal humerus bone, suggesting disturbance in normal ossification. Transient hypercalcemia before the development of hypocalcemia after maternal magnesium sulfate therapy has not been previously reported. We speculate that maternal long-term magnesium sulfate therapy led to defective ossification and transient hypercalcemia in the offspring. Subsequent hypocalcemia was thought to be due to the inhibition of parathyroid hormone secretion by hypercalcemia and hypermagnesemia. The Japanese Society for Pediatric Endocrinology 2021-12-26 2022 /pmc/articles/PMC8981048/ /pubmed/35431443 http://dx.doi.org/10.1297/cpe.2021-0061 Text en 2022©The Japanese Society for Pediatric Endocrinology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Case Report Tominaga, Takahiro Ikeda, Kazushige Awazu, Midori Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy |
title | Transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
title_full | Transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
title_fullStr | Transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
title_full_unstemmed | Transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
title_short | Transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
title_sort | transient hypercalcemia followed by hypocalcemia in a preterm infant after
maternal magnesium sulfate therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981048/ https://www.ncbi.nlm.nih.gov/pubmed/35431443 http://dx.doi.org/10.1297/cpe.2021-0061 |
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