Cargando…

Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy

Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of memb...

Descripción completa

Detalles Bibliográficos
Autores principales: Tominaga, Takahiro, Ikeda, Kazushige, Awazu, Midori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981048/
https://www.ncbi.nlm.nih.gov/pubmed/35431443
http://dx.doi.org/10.1297/cpe.2021-0061
_version_ 1784681521816272896
author Tominaga, Takahiro
Ikeda, Kazushige
Awazu, Midori
author_facet Tominaga, Takahiro
Ikeda, Kazushige
Awazu, Midori
author_sort Tominaga, Takahiro
collection PubMed
description Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of membranes for 32 days, and the patient was delivered at 33 weeks gestation. The cord blood showed ionized calcium 1.54 mmol/L. His serum calcium and magnesium were 11.4 mg/dL and 3.5 mg/dL after birth and fell to 6.6 mg/dL and 2.7 mg/dL at 6 hours, respectively. The intact parathyroid hormone level was 18 pg/mL at 6 h. Radiography showed transverse radiolucent metaphyseal bands of the proximal humerus bone, suggesting disturbance in normal ossification. Transient hypercalcemia before the development of hypocalcemia after maternal magnesium sulfate therapy has not been previously reported. We speculate that maternal long-term magnesium sulfate therapy led to defective ossification and transient hypercalcemia in the offspring. Subsequent hypocalcemia was thought to be due to the inhibition of parathyroid hormone secretion by hypercalcemia and hypermagnesemia.
format Online
Article
Text
id pubmed-8981048
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Japanese Society for Pediatric Endocrinology
record_format MEDLINE/PubMed
spelling pubmed-89810482022-04-15 Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy Tominaga, Takahiro Ikeda, Kazushige Awazu, Midori Clin Pediatr Endocrinol Case Report Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who presented hypercalcemia before developing hypocalcemia after maternal magnesium sulfate therapy. Magnesium sulfate was used for premature rupture of membranes for 32 days, and the patient was delivered at 33 weeks gestation. The cord blood showed ionized calcium 1.54 mmol/L. His serum calcium and magnesium were 11.4 mg/dL and 3.5 mg/dL after birth and fell to 6.6 mg/dL and 2.7 mg/dL at 6 hours, respectively. The intact parathyroid hormone level was 18 pg/mL at 6 h. Radiography showed transverse radiolucent metaphyseal bands of the proximal humerus bone, suggesting disturbance in normal ossification. Transient hypercalcemia before the development of hypocalcemia after maternal magnesium sulfate therapy has not been previously reported. We speculate that maternal long-term magnesium sulfate therapy led to defective ossification and transient hypercalcemia in the offspring. Subsequent hypocalcemia was thought to be due to the inhibition of parathyroid hormone secretion by hypercalcemia and hypermagnesemia. The Japanese Society for Pediatric Endocrinology 2021-12-26 2022 /pmc/articles/PMC8981048/ /pubmed/35431443 http://dx.doi.org/10.1297/cpe.2021-0061 Text en 2022©The Japanese Society for Pediatric Endocrinology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Case Report
Tominaga, Takahiro
Ikeda, Kazushige
Awazu, Midori
Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title_full Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title_fullStr Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title_full_unstemmed Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title_short Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
title_sort transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981048/
https://www.ncbi.nlm.nih.gov/pubmed/35431443
http://dx.doi.org/10.1297/cpe.2021-0061
work_keys_str_mv AT tominagatakahiro transienthypercalcemiafollowedbyhypocalcemiainapreterminfantaftermaternalmagnesiumsulfatetherapy
AT ikedakazushige transienthypercalcemiafollowedbyhypocalcemiainapreterminfantaftermaternalmagnesiumsulfatetherapy
AT awazumidori transienthypercalcemiafollowedbyhypocalcemiainapreterminfantaftermaternalmagnesiumsulfatetherapy