A highly selective and sensitive spectrofluorimetric method for the assessment of 3-nitrotyrosine in serum using (Eu(TTA)(3)Phen) photo probe

A simple, accurate and fast method was developed for the assessment of 3-nitrotyrosine as a biomarker for the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy (MHE) using a (Eu(TTA)(3)Phen) photo probe. 3-Nitrotyrosine can remarkably quench the luminescence intensity of the (Eu...

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Detalles Bibliográficos
Autores principales: Attia, Mohmed S., Youssef, Ahmed O., Abdel-Sattar, Nour A., Amin, Mohammed A., Alharthi, Sarah, Mohamed, Ekram H., Mahmoud, Safwat A., Abou-Omar, Mona N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981050/
https://www.ncbi.nlm.nih.gov/pubmed/35425515
http://dx.doi.org/10.1039/d1ra07351f
Descripción
Sumario:A simple, accurate and fast method was developed for the assessment of 3-nitrotyrosine as a biomarker for the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy (MHE) using a (Eu(TTA)(3)Phen) photo probe. 3-Nitrotyrosine can remarkably quench the luminescence intensity of the (Eu(TTA)(3)Phen) complex in DMSO at pH = 9 and λ(em) = 617 nm. The quenching of the luminescence intensity of (Eu(TTA)(3)Phen) complex particularly the electrical emission band at λ(em) = 617 nm is used for the assessment of 3-nitrotyrosine in different serum samples of patients with liver cirrhosis.

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