Cargando…

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial

IMPORTANCE: Daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, is being evaluated as an oral alternative to conventional erythropoiesis-stimulating agent (ESA) therapy. Few studies of anemia treatment in an incident dialysis (ID) population have been reported. OBJECTIVE: To evalua...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Ajay K., Cizman, Borut, Carroll, Kevin, McMurray, John J. V., Perkovic, Vlado, Jha, Vivekanand, Johansen, Kirsten L., Lopes, Renato D., Macdougall, Iain C., Obrador, Gregorio T., Waikar, Sushrut S., Wanner, Christoph, Wheeler, David C., Wiecek, Andrzej, Stankus, Nicole, Strutz, Frank, Blackorby, Allison, Cobitz, Alexander R., Meadowcroft, Amy M., Paul, Gitanjali, Ranganathan, Prerna, Sedani, Sangeeta, Solomon, Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2022
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981070/ https://www.ncbi.nlm.nih.gov/pubmed/35377393 http://dx.doi.org/10.1001/jamainternmed.2022.0605

Ejemplares similares

Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D)
por: Macdougall, Iain C., et al.
Publicado: (2023)

Study design and baseline characteristics of patients on dialysis in the ASCEND-D trial
por: Singh, Ajay K, et al.
Publicado: (2021)

An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects
por: Cizman, Borut, et al.
Publicado: (2018)

The ASCEND-ND trial: study design and participant characteristics
por: Perkovic, Vlado, et al.
Publicado: (2021)

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis
por: Meadowcroft, Amy M, et al.
Publicado: (2018)

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease
por: Holdstock, Louis, et al.
Publicado: (2018)

Effect of renal function and dialysis modality on daprodustat and predominant metabolite exposure
por: Caltabiano, Stephen, et al.
Publicado: (2019)

The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects
por: Caltabiano, Stephen, et al.
Publicado: (2018)

Efficacy and safety of daprodustat in Japanese peritoneal dialysis patients
por: Kanai, Hidetoshi, et al.
Publicado: (2021)

Pharmacokinetics of Daprodustat and Metabolites in Individuals with Normal and Impaired Hepatic Function
por: Mahar, Kelly M., et al.
Publicado: (2022)

Daprodustat: First Approval
por: Dhillon, Sohita
Publicado: (2020)

Safety of daprodustat in patients with anemia of chronic kidney disease: A pooled analysis of phase 3 studies in Japan
por: Nangaku, Masaomi, et al.
Publicado: (2022)

A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis
por: Bailey, Christine K., et al.
Publicado: (2019)

Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioavailability Determination
por: Mahar, Kelly M., et al.
Publicado: (2021)

Profile of Daprodustat in the Treatment of Renal Anemia Due to Chronic Kidney Disease
por: Ishii, Taisuke, et al.
Publicado: (2021)

Daprodustat: A potential game-changer in renal anemia therapy—A perspective
por: Haider, Muhammad Usman, et al.
Publicado: (2023)

Anemia and mortality in patients with nondialysis-dependent chronic kidney disease
por: Stirnadel-Farrant, Heide A., et al.
Publicado: (2018)

An Emerging Treatment Alternative for Anemia in Chronic Kidney Disease Patients: A Review of Daprodustat
por: Becker, Kimberly A., et al.
Publicado: (2017)

Daprodustat Accelerates High Phosphate-Induced Calcification Through the Activation of HIF-1 Signaling
por: Tóth, Andrea, et al.
Publicado: (2022)

Daprodustat for anaemia in patients with heart failure and chronic kidney disease: A randomized controlled study
por: Iso, Takashi, et al.
Publicado: (2022)

Cardiovascular Event Rates Among Hemodialysis Patients Across Geographical Regions—A Snapshot From The Dialysis Outcomes and Practice Patterns Study (DOPPS)
por: Stirnadel-Farrant, Heide A., et al.
Publicado: (2019)

Efficacy and Safety of Daprodustat for Anemia Therapy in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis
por: Zheng, Qiyan, et al.
Publicado: (2021)

Time to Expand Access and Utilization of Home Dialysis: Lessons From the COVID-19 Pandemic
por: Stern, Lauren D., et al.
Publicado: (2020)

Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string
por: Tai, Guoying, et al.
Publicado: (2023)

New hypoglycemic agents and the kidney: what do the major trials tell us?
por: Smyth, Brendan, et al.
Publicado: (2018)

Performance of the Automated Urinalysis in Diagnosis of Proliferative Glomerulonephritis
por: Palsson, Ragnar, et al.
Publicado: (2019)

Evaluating the feasibility of the KDIGO CKD referral recommendations
por: Singh, Karandeep, et al.
Publicado: (2017)

Severe hyponatremia due to surreptitious water intoxication in a hospitalized patient
por: Claudel, Sophie E., et al.
Publicado: (2022)

Blood pressure: at what level is treatment worthwhile?
por: Atkins, Emily R, et al.
Publicado: (2019)

Efficacy and Safety of Daprodustat Vs rhEPO for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis
por: Fu, Zhangning, et al.
Publicado: (2022)

Efficacy of Different Doses of Daprodustat for Anemic Non-dialysis Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis
por: Fadlalmola, Hammad, et al.
Publicado: (2022)

Nephrology co-management versus primary care solo management for early chronic kidney disease: a retrospective cross-sectional analysis
por: Samal, Lipika, et al.
Publicado: (2015)

Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference
por: Baigent, Colin, et al.
Publicado: (2017)

A Single‐Dose, Open‐Label, Randomized, Two‐Way Crossover Study in Healthy Japanese Participants to Evaluate the Bioequivalence and the Food Effect on the Pharmacokinetics of Daprodustat
por: Yamada, Masanori, et al.
Publicado: (2020)

Needle Size and the Risk of Kidney Biopsy Bleeding Complications
por: Cui, Salena, et al.
Publicado: (2016)

Dietary Oxalate Intake and Kidney Outcomes
por: Bargagli, Matteo, et al.
Publicado: (2020)

Caring for Dialysis Patients in a Time of COVID-19
por: Verma, Ashish, et al.
Publicado: (2020)

COVID-19 Infection Risk Among Hemodialysis Patients in Long-term Care Facilities
por: Liu, Christine K., et al.
Publicado: (2020)

Machine Learning Applications in Nephrology: A Bibliometric Analysis Comparing Kidney Studies to Other Medicine Subspecialities
por: Verma, Ashish, et al.
Publicado: (2021)

Kidney Disease–Related Mortality Among Asian Americans
por: Claudel, Sophie E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f4bt28ghjaf45e4vek0i1u3698