Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange

Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para-hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represents...

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Detalles Bibliográficos
Autores principales: Jeong, Hye Jin, Min, Sein, Kim, Sarah, Namgoong, Sung Keon, Jeong, Keunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981083/
https://www.ncbi.nlm.nih.gov/pubmed/35425403
http://dx.doi.org/10.1039/d2ra00062h
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author Jeong, Hye Jin
Min, Sein
Kim, Sarah
Namgoong, Sung Keon
Jeong, Keunhong
author_facet Jeong, Hye Jin
Min, Sein
Kim, Sarah
Namgoong, Sung Keon
Jeong, Keunhong
author_sort Jeong, Hye Jin
collection PubMed
description Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para-hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represents the first successful para-hydrogen based hyperpolarization application in biological reaction monitoring.
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spelling pubmed-89810832022-04-13 Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange Jeong, Hye Jin Min, Sein Kim, Sarah Namgoong, Sung Keon Jeong, Keunhong RSC Adv Chemistry Our experiments indicate hyperpolarized proton signals in the entire structure of remdesivir are obtained due to a long-distance polarization transfer by para-hydrogen. SABRE-based biological real-time reaction monitoring, by using a protein enzyme under mild conditions is carried out. It represents the first successful para-hydrogen based hyperpolarization application in biological reaction monitoring. The Royal Society of Chemistry 2022-02-02 /pmc/articles/PMC8981083/ /pubmed/35425403 http://dx.doi.org/10.1039/d2ra00062h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jeong, Hye Jin
Min, Sein
Kim, Sarah
Namgoong, Sung Keon
Jeong, Keunhong
Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title_full Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title_fullStr Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title_full_unstemmed Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title_short Hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
title_sort hyperpolarization study on remdesivir with its biological reaction monitoring via signal amplification by reversible exchange
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981083/
https://www.ncbi.nlm.nih.gov/pubmed/35425403
http://dx.doi.org/10.1039/d2ra00062h
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