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An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection

The ongoing pandemic of COVID-19 has elaborated an idiosyncratic pattern of SARS-CoV-2-induced symptoms in the human host. Some populations have succumbed to the SARS-CoV-2 infection in large numbers during this pandemic, whereas others have shown a resilient side by manifesting only milder or no sy...

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Autores principales: Raza, Rabail Zehra, Abbasi, Sumra Wajid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981084/
https://www.ncbi.nlm.nih.gov/pubmed/35391792
http://dx.doi.org/10.3389/fgene.2022.859508
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author Raza, Rabail Zehra
Abbasi, Sumra Wajid
author_facet Raza, Rabail Zehra
Abbasi, Sumra Wajid
author_sort Raza, Rabail Zehra
collection PubMed
description The ongoing pandemic of COVID-19 has elaborated an idiosyncratic pattern of SARS-CoV-2-induced symptoms in the human host. Some populations have succumbed to the SARS-CoV-2 infection in large numbers during this pandemic, whereas others have shown a resilient side by manifesting only milder or no symptoms at all. This observation has relayed the onus of the heterogeneous pattern of SARS-CoV-2-induced critical illness among different populations to the host genetic factors. Here, the evolutionary route was explored and three genetic loci, i.e., rs10735079, rs2109069, and rs2236757, associated with COVID-19 were analyzed. Among the three, the risk allele A at genetic locus rs2236757 residing in the IFNAR2 gene was observed to have undergone recent positive selection in the African population.
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spelling pubmed-89810842022-04-06 An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection Raza, Rabail Zehra Abbasi, Sumra Wajid Front Genet Genetics The ongoing pandemic of COVID-19 has elaborated an idiosyncratic pattern of SARS-CoV-2-induced symptoms in the human host. Some populations have succumbed to the SARS-CoV-2 infection in large numbers during this pandemic, whereas others have shown a resilient side by manifesting only milder or no symptoms at all. This observation has relayed the onus of the heterogeneous pattern of SARS-CoV-2-induced critical illness among different populations to the host genetic factors. Here, the evolutionary route was explored and three genetic loci, i.e., rs10735079, rs2109069, and rs2236757, associated with COVID-19 were analyzed. Among the three, the risk allele A at genetic locus rs2236757 residing in the IFNAR2 gene was observed to have undergone recent positive selection in the African population. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8981084/ /pubmed/35391792 http://dx.doi.org/10.3389/fgene.2022.859508 Text en Copyright © 2022 Raza and Abbasi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Raza, Rabail Zehra
Abbasi, Sumra Wajid
An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title_full An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title_fullStr An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title_full_unstemmed An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title_short An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection
title_sort evolutionary insight into the heterogeneous severity pattern of the sars-cov-2 infection
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981084/
https://www.ncbi.nlm.nih.gov/pubmed/35391792
http://dx.doi.org/10.3389/fgene.2022.859508
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