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Diastereoselective synthesis of new zwitterionic bicyclic lactams, scaffolds for construction of 2-substituted-4-hydroxy piperidine and its pipecolic acid derivatives

The synthesis of new chiral highly functionalized zwitterionic bicyclic lactams starting from acyclic β-enaminoesters derived from (R)-(−)-2-phenylglycinol is described. The key step involved an intramolecular non-classical Corey–Chaykovsky ring-closing reaction of the corresponding sulfonium salts...

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Detalles Bibliográficos
Autores principales:	Reyes-Bravo, Enrique, Gnecco, Dino, Juárez, Jorge R., Orea, María L., Bernès, Sylvain, Aparicio, David M., Terán, Joel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981097/ https://www.ncbi.nlm.nih.gov/pubmed/35425406 http://dx.doi.org/10.1039/d1ra09298g

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