Conduction properties of the preferential pathway in a patient with idiopathic outflow ventricular arrhythmia

Ventricular arrhythmias (VA) originating from the outflow tract often conduct via a preferential pathway into a distant breakout site in the ventricular myocardium. Preferential pathway potentials, characterized as presystolic potentials preceding the QRS onset during VA and late potentials during sinus rhythm, are known targets of successful cardiac ablation. However, the mechanism of conduction and properties of the preferential pathway has not yet been fully elucidated. In the present case, we evaluated the conduction properties of the preferential pathway using 3D electrical mapping in a patient with VA originating from the left ventricular outflow tract. Similar to the embryonic cardiomyocyte, slow conduction velocity, decremental property, and automaticity were found in the preferential pathway. Thus, the preferential pathway may be considered a remnant of the developing conduction system as so-called “dead end tract,” rather than the typical structures such as the LV myocardium or Purkinje tissue.