Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as Sirt1 inhibitors

Owing to its presence in several biological processes, Sirt1 acts as a potential therapeutic target for many diseases. Here, we report the structure-based designing and synthesis of two distinct series of novel Sirt1 inhibitors, benzimidazole mono-peptides and amino-acid derived 5-pyrazolyl methylid...

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Detalles Bibliográficos
Autores principales: Purushotham, Nikil, Singh, Mrityunjay, Paramesha, Bugga, Kumar, Vasantha, Wakode, Sharad, Banerjee, Sanjay K., Poojary, Boja, Asthana, Shailendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981170/
https://www.ncbi.nlm.nih.gov/pubmed/35425455
http://dx.doi.org/10.1039/d1ra06149f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981170/
https://www.ncbi.nlm.nih.gov/pubmed/35425455
http://dx.doi.org/10.1039/d1ra06149f

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