Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report

BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesi...

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Autores principales: Berek, Klaus, Beer, Ronny, Grams, Astrid, Helbok, Raimund, Lindner, Anna, Pfausler, Bettina, Schiefecker, Alois, Deisenhammer, Florian, Hegen, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981196/
https://www.ncbi.nlm.nih.gov/pubmed/35382753
http://dx.doi.org/10.1186/s12883-022-02637-x
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author Berek, Klaus
Beer, Ronny
Grams, Astrid
Helbok, Raimund
Lindner, Anna
Pfausler, Bettina
Schiefecker, Alois
Deisenhammer, Florian
Hegen, Harald
author_facet Berek, Klaus
Beer, Ronny
Grams, Astrid
Helbok, Raimund
Lindner, Anna
Pfausler, Bettina
Schiefecker, Alois
Deisenhammer, Florian
Hegen, Harald
author_sort Berek, Klaus
collection PubMed
description BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2). CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.
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spelling pubmed-89811962022-04-05 Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report Berek, Klaus Beer, Ronny Grams, Astrid Helbok, Raimund Lindner, Anna Pfausler, Bettina Schiefecker, Alois Deisenhammer, Florian Hegen, Harald BMC Neurol Case Report BACKGROUND: Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2). CONCLUSION: This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies. BioMed Central 2022-04-05 /pmc/articles/PMC8981196/ /pubmed/35382753 http://dx.doi.org/10.1186/s12883-022-02637-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Berek, Klaus
Beer, Ronny
Grams, Astrid
Helbok, Raimund
Lindner, Anna
Pfausler, Bettina
Schiefecker, Alois
Deisenhammer, Florian
Hegen, Harald
Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title_full Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title_fullStr Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title_full_unstemmed Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title_short Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
title_sort caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981196/
https://www.ncbi.nlm.nih.gov/pubmed/35382753
http://dx.doi.org/10.1186/s12883-022-02637-x
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