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Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study

OBJECTIVE: Our knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms. METHODS: This i...

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Autores principales: Comelli, Agnese, Viero, Giulia, Bettini, Greta, Nobili, Alessandro, Tettamanti, Mauro, Galbussera, Alessia Antonella, Muscatello, Antonio, Mantero, Marco, Canetta, Ciro, Martinelli Boneschi, Filippo, Arighi, Andrea, Brambilla, Paolo, Vecchi, Maurizio, Lampertico, Pietro, Bonfanti, Paolo, Contoli, Marco, Blasi, Francesco, Gori, Andrea, Bandera, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981315/
https://www.ncbi.nlm.nih.gov/pubmed/35391879
http://dx.doi.org/10.3389/fmed.2022.834354
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author Comelli, Agnese
Viero, Giulia
Bettini, Greta
Nobili, Alessandro
Tettamanti, Mauro
Galbussera, Alessia Antonella
Muscatello, Antonio
Mantero, Marco
Canetta, Ciro
Martinelli Boneschi, Filippo
Arighi, Andrea
Brambilla, Paolo
Vecchi, Maurizio
Lampertico, Pietro
Bonfanti, Paolo
Contoli, Marco
Blasi, Francesco
Gori, Andrea
Bandera, Alessandra
author_facet Comelli, Agnese
Viero, Giulia
Bettini, Greta
Nobili, Alessandro
Tettamanti, Mauro
Galbussera, Alessia Antonella
Muscatello, Antonio
Mantero, Marco
Canetta, Ciro
Martinelli Boneschi, Filippo
Arighi, Andrea
Brambilla, Paolo
Vecchi, Maurizio
Lampertico, Pietro
Bonfanti, Paolo
Contoli, Marco
Blasi, Francesco
Gori, Andrea
Bandera, Alessandra
author_sort Comelli, Agnese
collection PubMed
description OBJECTIVE: Our knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms. METHODS: This is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020. RESULTS: Among the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19. CONCLUSIONS: Patient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions.
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spelling pubmed-89813152022-04-06 Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study Comelli, Agnese Viero, Giulia Bettini, Greta Nobili, Alessandro Tettamanti, Mauro Galbussera, Alessia Antonella Muscatello, Antonio Mantero, Marco Canetta, Ciro Martinelli Boneschi, Filippo Arighi, Andrea Brambilla, Paolo Vecchi, Maurizio Lampertico, Pietro Bonfanti, Paolo Contoli, Marco Blasi, Francesco Gori, Andrea Bandera, Alessandra Front Med (Lausanne) Medicine OBJECTIVE: Our knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms. METHODS: This is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020. RESULTS: Among the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19. CONCLUSIONS: Patient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8981315/ /pubmed/35391879 http://dx.doi.org/10.3389/fmed.2022.834354 Text en Copyright © 2022 Comelli, Viero, Bettini, Nobili, Tettamanti, Galbussera, Muscatello, Mantero, Canetta, Martinelli Boneschi, Arighi, Brambilla, Vecchi, Lampertico, Bonfanti, Contoli, Blasi, Gori, Bandera. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Comelli, Agnese
Viero, Giulia
Bettini, Greta
Nobili, Alessandro
Tettamanti, Mauro
Galbussera, Alessia Antonella
Muscatello, Antonio
Mantero, Marco
Canetta, Ciro
Martinelli Boneschi, Filippo
Arighi, Andrea
Brambilla, Paolo
Vecchi, Maurizio
Lampertico, Pietro
Bonfanti, Paolo
Contoli, Marco
Blasi, Francesco
Gori, Andrea
Bandera, Alessandra
Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title_full Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title_fullStr Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title_full_unstemmed Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title_short Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
title_sort patient-reported symptoms and sequelae 12 months after covid-19 in hospitalized adults: a multicenter long-term follow-up study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981315/
https://www.ncbi.nlm.nih.gov/pubmed/35391879
http://dx.doi.org/10.3389/fmed.2022.834354
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