Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process

A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by T(1)...

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Autores principales: Utomo, Rohmad Yudi, Okada, Satoshi, Sumiyoshi, Akira, Aoki, Ichio, Nakamura, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981495/
https://www.ncbi.nlm.nih.gov/pubmed/35425501
http://dx.doi.org/10.1039/d2ra00614f
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author Utomo, Rohmad Yudi
Okada, Satoshi
Sumiyoshi, Akira
Aoki, Ichio
Nakamura, Hiroyuki
author_facet Utomo, Rohmad Yudi
Okada, Satoshi
Sumiyoshi, Akira
Aoki, Ichio
Nakamura, Hiroyuki
author_sort Utomo, Rohmad Yudi
collection PubMed
description A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by T(1)-weighted MR imaging.
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spelling pubmed-89814952022-04-13 Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process Utomo, Rohmad Yudi Okada, Satoshi Sumiyoshi, Akira Aoki, Ichio Nakamura, Hiroyuki RSC Adv Chemistry A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by T(1)-weighted MR imaging. The Royal Society of Chemistry 2022-02-09 /pmc/articles/PMC8981495/ /pubmed/35425501 http://dx.doi.org/10.1039/d2ra00614f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Utomo, Rohmad Yudi
Okada, Satoshi
Sumiyoshi, Akira
Aoki, Ichio
Nakamura, Hiroyuki
Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title_full Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title_fullStr Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title_full_unstemmed Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title_short Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
title_sort development of an mri contrast agent for both detection and inhibition of the amyloid-β fibrillation process
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981495/
https://www.ncbi.nlm.nih.gov/pubmed/35425501
http://dx.doi.org/10.1039/d2ra00614f
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AT sumiyoshiakira developmentofanmricontrastagentforbothdetectionandinhibitionoftheamyloidbfibrillationprocess
AT aokiichio developmentofanmricontrastagentforbothdetectionandinhibitionoftheamyloidbfibrillationprocess
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