Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process

A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by T(1)...

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Detalles Bibliográficos
Autores principales: Utomo, Rohmad Yudi, Okada, Satoshi, Sumiyoshi, Akira, Aoki, Ichio, Nakamura, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981495/
https://www.ncbi.nlm.nih.gov/pubmed/35425501
http://dx.doi.org/10.1039/d2ra00614f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981495/
https://www.ncbi.nlm.nih.gov/pubmed/35425501
http://dx.doi.org/10.1039/d2ra00614f

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