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Influence of sequence variation on the RNA cleavage activity of Zn(2+)-dimethyl-dppz-PNA-based artificial enzymes

The development of Zn(2+)-dependent dimethyl-dppz-PNA conjugates (PNAzymes) as efficient site-specific artificial ribonucleases enables rapid sequence-specific degradation of clinically relevant RNA target sequences, but the significance of the RNA/PNAzyme sequence and structural demands for the ide...

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Detalles Bibliográficos
Autores principales:	Luige, Olivia, Karalė, Kristina, Bose, Partha Pratim, Bollmark, Martin, Tedebark, Ulf, Murtola, Merita, Strömberg, Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981518/ https://www.ncbi.nlm.nih.gov/pubmed/35425588 http://dx.doi.org/10.1039/d1ra08319h

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