Polar/apolar interfaces modulate the conformational behavior of cyclic peptides with impact on their passive membrane permeability

Cyclic peptides have the potential to vastly extend the scope of druggable proteins and lead to new therapeutics for currently untreatable diseases. However, cyclic peptides often suffer from poor bioavailability. To uncover design principles for permeable cyclic peptides, a promising strategy is to...

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Detalles Bibliográficos
Autores principales: Linker, Stephanie M., Schellhaas, Christian, Ries, Benjamin, Roth, Hans-Jörg, Fouché, Marianne, Rodde, Stephane, Riniker, Sereina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981571/
https://www.ncbi.nlm.nih.gov/pubmed/35424539
http://dx.doi.org/10.1039/d1ra09025a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981571/
https://www.ncbi.nlm.nih.gov/pubmed/35424539
http://dx.doi.org/10.1039/d1ra09025a

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