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Polar/apolar interfaces modulate the conformational behavior of cyclic peptides with impact on their passive membrane permeability
Cyclic peptides have the potential to vastly extend the scope of druggable proteins and lead to new therapeutics for currently untreatable diseases. However, cyclic peptides often suffer from poor bioavailability. To uncover design principles for permeable cyclic peptides, a promising strategy is to...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981571/ https://www.ncbi.nlm.nih.gov/pubmed/35424539 http://dx.doi.org/10.1039/d1ra09025a |