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Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer’s disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt(−/−) mice, suggesting that tau protein is required for these effects of Aβ. However, whether some synapses are more selectively af...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981624/ https://www.ncbi.nlm.nih.gov/pubmed/35379353 http://dx.doi.org/10.1186/s40478-022-01350-7 |