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Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ

Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer’s disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt(−/−) mice, suggesting that tau protein is required for these effects of Aβ. However, whether some synapses are more selectively af...

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Detalles Bibliográficos
Autores principales:	Shipton, Olivia A., Tang, Clara S., Paulsen, Ole, Vargas-Caballero, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981624/ https://www.ncbi.nlm.nih.gov/pubmed/35379353 http://dx.doi.org/10.1186/s40478-022-01350-7

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