Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

OBJECTIVE: Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent w...

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Autores principales: Lee, Hanna, Suh, Young Sun, Lee, Sang-Il, Cheon, Yun-Hong, Kim, Mingyo, Noh, Hae Sook, Kim, Hyun-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981634/
https://www.ncbi.nlm.nih.gov/pubmed/35382860
http://dx.doi.org/10.1186/s13104-022-06008-0
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author Lee, Hanna
Suh, Young Sun
Lee, Sang-Il
Cheon, Yun-Hong
Kim, Mingyo
Noh, Hae Sook
Kim, Hyun-Ok
author_facet Lee, Hanna
Suh, Young Sun
Lee, Sang-Il
Cheon, Yun-Hong
Kim, Mingyo
Noh, Hae Sook
Kim, Hyun-Ok
author_sort Lee, Hanna
collection PubMed
description OBJECTIVE: Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results. RESULTS: The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman’s rho = 0.583, p < 0.001).
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spelling pubmed-89816342022-04-06 Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity Lee, Hanna Suh, Young Sun Lee, Sang-Il Cheon, Yun-Hong Kim, Mingyo Noh, Hae Sook Kim, Hyun-Ok BMC Res Notes Research Note OBJECTIVE: Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results. RESULTS: The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman’s rho = 0.583, p < 0.001). BioMed Central 2022-04-05 /pmc/articles/PMC8981634/ /pubmed/35382860 http://dx.doi.org/10.1186/s13104-022-06008-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Lee, Hanna
Suh, Young Sun
Lee, Sang-Il
Cheon, Yun-Hong
Kim, Mingyo
Noh, Hae Sook
Kim, Hyun-Ok
Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title_full Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title_fullStr Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title_full_unstemmed Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title_short Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
title_sort serum igf-1 in patients with rheumatoid arthritis: correlation with disease activity
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981634/
https://www.ncbi.nlm.nih.gov/pubmed/35382860
http://dx.doi.org/10.1186/s13104-022-06008-0
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