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Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization
Liquid molecules are difficult to crystallize, and their structures and absolute configurations cannot be directly determined by X-ray crystallography. We herein report the rapid cocrystallization of tetraaryladamantanes with liquid molecules. The structure of the liquid small molecules can be obtai...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981717/ https://www.ncbi.nlm.nih.gov/pubmed/35424635 http://dx.doi.org/10.1039/d1ra09284g |
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author | Ou, Guang-Chuan Chen, Hai-Yang Wang, Qiong Zhou, Qiang Zeng, Fei |
author_facet | Ou, Guang-Chuan Chen, Hai-Yang Wang, Qiong Zhou, Qiang Zeng, Fei |
author_sort | Ou, Guang-Chuan |
collection | PubMed |
description | Liquid molecules are difficult to crystallize, and their structures and absolute configurations cannot be directly determined by X-ray crystallography. We herein report the rapid cocrystallization of tetraaryladamantanes with liquid molecules. The structure of the liquid small molecules can be obtained by determining the crystal structure of the cocrystallized compound. The absolute configuration of chiral molecules can also be assigned, which cannot be accomplished by other methods such as nuclear magnetic resonance. In this paper, liquid compounds such as phenylethanol and phenylpropanol derivatives were selected. 1,3,5,7-Tetrakis(2,4-diethoxyphenyl)adamantane (TEO) powder was heated and dissolved in liquid molecules and allowed to stand overnight to undergo cocrystallization. The results show that the single-crystal structures and the absolute configurations of 16 liquid molecules were determined by cocrystallization, and the homochiral natures of chiral compounds were confirmed by solid circular dichroism spectral measurements. |
format | Online Article Text |
id | pubmed-8981717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-89817172022-04-13 Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization Ou, Guang-Chuan Chen, Hai-Yang Wang, Qiong Zhou, Qiang Zeng, Fei RSC Adv Chemistry Liquid molecules are difficult to crystallize, and their structures and absolute configurations cannot be directly determined by X-ray crystallography. We herein report the rapid cocrystallization of tetraaryladamantanes with liquid molecules. The structure of the liquid small molecules can be obtained by determining the crystal structure of the cocrystallized compound. The absolute configuration of chiral molecules can also be assigned, which cannot be accomplished by other methods such as nuclear magnetic resonance. In this paper, liquid compounds such as phenylethanol and phenylpropanol derivatives were selected. 1,3,5,7-Tetrakis(2,4-diethoxyphenyl)adamantane (TEO) powder was heated and dissolved in liquid molecules and allowed to stand overnight to undergo cocrystallization. The results show that the single-crystal structures and the absolute configurations of 16 liquid molecules were determined by cocrystallization, and the homochiral natures of chiral compounds were confirmed by solid circular dichroism spectral measurements. The Royal Society of Chemistry 2022-02-23 /pmc/articles/PMC8981717/ /pubmed/35424635 http://dx.doi.org/10.1039/d1ra09284g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Ou, Guang-Chuan Chen, Hai-Yang Wang, Qiong Zhou, Qiang Zeng, Fei Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title | Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title_full | Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title_fullStr | Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title_full_unstemmed | Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title_short | Structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
title_sort | structure and absolute configuration of liquid molecules based on adamantane derivative cocrystallization |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981717/ https://www.ncbi.nlm.nih.gov/pubmed/35424635 http://dx.doi.org/10.1039/d1ra09284g |
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