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Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation

Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascu...

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Autores principales: Barry, Mark, Pati, Shibani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981767/
https://www.ncbi.nlm.nih.gov/pubmed/35392184
http://dx.doi.org/10.1016/j.mbplus.2022.100107
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author Barry, Mark
Pati, Shibani
author_facet Barry, Mark
Pati, Shibani
author_sort Barry, Mark
collection PubMed
description Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascular barrier, and plays a critical role in the pathogenesis of multiple organ dysfunction, leading to poor outcomes in trauma patients. In this review we discuss (i) the pathophysiology of endothelial glycocalyx and vascular barrier breakdown following hemorrhagic shock and trauma, and (ii) the role of plasma and platelet transfusion in maintaining the glycocalyx and vascular endothelial integrity.
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spelling pubmed-89817672022-04-06 Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation Barry, Mark Pati, Shibani Matrix Biol Plus Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson. Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascular barrier, and plays a critical role in the pathogenesis of multiple organ dysfunction, leading to poor outcomes in trauma patients. In this review we discuss (i) the pathophysiology of endothelial glycocalyx and vascular barrier breakdown following hemorrhagic shock and trauma, and (ii) the role of plasma and platelet transfusion in maintaining the glycocalyx and vascular endothelial integrity. Elsevier 2022-03-17 /pmc/articles/PMC8981767/ /pubmed/35392184 http://dx.doi.org/10.1016/j.mbplus.2022.100107 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson.
Barry, Mark
Pati, Shibani
Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title_full Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title_fullStr Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title_full_unstemmed Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title_short Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
title_sort targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
topic Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981767/
https://www.ncbi.nlm.nih.gov/pubmed/35392184
http://dx.doi.org/10.1016/j.mbplus.2022.100107
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