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Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation
Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981767/ https://www.ncbi.nlm.nih.gov/pubmed/35392184 http://dx.doi.org/10.1016/j.mbplus.2022.100107 |
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author | Barry, Mark Pati, Shibani |
author_facet | Barry, Mark Pati, Shibani |
author_sort | Barry, Mark |
collection | PubMed |
description | Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascular barrier, and plays a critical role in the pathogenesis of multiple organ dysfunction, leading to poor outcomes in trauma patients. In this review we discuss (i) the pathophysiology of endothelial glycocalyx and vascular barrier breakdown following hemorrhagic shock and trauma, and (ii) the role of plasma and platelet transfusion in maintaining the glycocalyx and vascular endothelial integrity. |
format | Online Article Text |
id | pubmed-8981767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89817672022-04-06 Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation Barry, Mark Pati, Shibani Matrix Biol Plus Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson. Severely injured patients with hemorrhagic shock can develop endothelial dysfunction, systemic inflammation, and coagulation disturbances collectively known as the endotheliopathy of trauma (EOT). Shedding of the endothelial glycocalyx occurs early after injury, contributes to breakdown of the vascular barrier, and plays a critical role in the pathogenesis of multiple organ dysfunction, leading to poor outcomes in trauma patients. In this review we discuss (i) the pathophysiology of endothelial glycocalyx and vascular barrier breakdown following hemorrhagic shock and trauma, and (ii) the role of plasma and platelet transfusion in maintaining the glycocalyx and vascular endothelial integrity. Elsevier 2022-03-17 /pmc/articles/PMC8981767/ /pubmed/35392184 http://dx.doi.org/10.1016/j.mbplus.2022.100107 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson. Barry, Mark Pati, Shibani Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title | Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title_full | Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title_fullStr | Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title_full_unstemmed | Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title_short | Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
title_sort | targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation |
topic | Special Section on The Glycocalyx: Pathobiology and Repair; Edited by Jillian Richter & Ralph Sanderson. |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981767/ https://www.ncbi.nlm.nih.gov/pubmed/35392184 http://dx.doi.org/10.1016/j.mbplus.2022.100107 |
work_keys_str_mv | AT barrymark targetingrepairofthevascularendotheliumandglycocalyxaftertraumaticinjurywithplasmaandplateletresuscitation AT patishibani targetingrepairofthevascularendotheliumandglycocalyxaftertraumaticinjurywithplasmaandplateletresuscitation |