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Mical modulates Tau toxicity via cysteine oxidation in vivo

Tau accumulation is clearly linked to pathogenesis in Alzheimer’s disease and other Tauopathies. However, processes leading to Tau fibrillization and reasons for its pathogenicity remain largely elusive. Mical emerged as a novel interacting protein of human Tau expressed in Drosophila brains. Mical...

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Detalles Bibliográficos
Autores principales: Prifti, Engie, Tsakiri, Eleni N., Vourkou, Ergina, Stamatakis, George, Samiotaki, Martina, Skoulakis, Efthimios M. C., Papanikolopoulou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981811/
https://www.ncbi.nlm.nih.gov/pubmed/35379354
http://dx.doi.org/10.1186/s40478-022-01348-1