A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization

I(2)/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I(2)/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino reaction. Simple and avai...

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Detalles Bibliográficos
Autores principales: Wang, Yishou, Li, Shichen, Wang, Xinfeng, Yao, Yiming, Feng, Lei, Ma, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981869/
https://www.ncbi.nlm.nih.gov/pubmed/35424560
http://dx.doi.org/10.1039/d1ra07438e
Descripción
Sumario:I(2)/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I(2)/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

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