A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization

I(2)/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I(2)/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino reaction. Simple and avai...

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Autores principales: Wang, Yishou, Li, Shichen, Wang, Xinfeng, Yao, Yiming, Feng, Lei, Ma, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981869/
https://www.ncbi.nlm.nih.gov/pubmed/35424560
http://dx.doi.org/10.1039/d1ra07438e
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author Wang, Yishou
Li, Shichen
Wang, Xinfeng
Yao, Yiming
Feng, Lei
Ma, Chen
author_facet Wang, Yishou
Li, Shichen
Wang, Xinfeng
Yao, Yiming
Feng, Lei
Ma, Chen
author_sort Wang, Yishou
collection PubMed
description I(2)/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I(2)/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.
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spelling pubmed-89818692022-04-13 A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization Wang, Yishou Li, Shichen Wang, Xinfeng Yao, Yiming Feng, Lei Ma, Chen RSC Adv Chemistry I(2)/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I(2)/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method. The Royal Society of Chemistry 2022-02-17 /pmc/articles/PMC8981869/ /pubmed/35424560 http://dx.doi.org/10.1039/d1ra07438e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Yishou
Li, Shichen
Wang, Xinfeng
Yao, Yiming
Feng, Lei
Ma, Chen
A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title_full A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title_fullStr A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title_full_unstemmed A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title_short A multi pathway coupled domino strategy: I(2)/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp C–H functionalization
title_sort multi pathway coupled domino strategy: i(2)/tbhp-promoted synthesis of imidazopyridines and thiazoles via sp(3), sp(2) and sp c–h functionalization
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981869/
https://www.ncbi.nlm.nih.gov/pubmed/35424560
http://dx.doi.org/10.1039/d1ra07438e
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