Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions

Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al(2)O(3) nanocomposite catal...

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Autores principales: Hernandez R., Rafael A., Burchell-Reyes, Kelly, Braga, Arthur P. C. A., Lopez, Jennifer Keough, Forgione, Pat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981965/
https://www.ncbi.nlm.nih.gov/pubmed/35424611
http://dx.doi.org/10.1039/d1ra08443g
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author Hernandez R., Rafael A.
Burchell-Reyes, Kelly
Braga, Arthur P. C. A.
Lopez, Jennifer Keough
Forgione, Pat
author_facet Hernandez R., Rafael A.
Burchell-Reyes, Kelly
Braga, Arthur P. C. A.
Lopez, Jennifer Keough
Forgione, Pat
author_sort Hernandez R., Rafael A.
collection PubMed
description Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al(2)O(3) nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations.
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spelling pubmed-89819652022-04-13 Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions Hernandez R., Rafael A. Burchell-Reyes, Kelly Braga, Arthur P. C. A. Lopez, Jennifer Keough Forgione, Pat RSC Adv Chemistry Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al(2)O(3) nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations. The Royal Society of Chemistry 2022-02-23 /pmc/articles/PMC8981965/ /pubmed/35424611 http://dx.doi.org/10.1039/d1ra08443g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hernandez R., Rafael A.
Burchell-Reyes, Kelly
Braga, Arthur P. C. A.
Lopez, Jennifer Keough
Forgione, Pat
Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title_full Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title_fullStr Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title_full_unstemmed Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title_short Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions
title_sort solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over cu/al(2)o(3) surface under ball-milling conditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981965/
https://www.ncbi.nlm.nih.gov/pubmed/35424611
http://dx.doi.org/10.1039/d1ra08443g
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