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Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al(2)O(3) surface under ball-milling conditions

Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al(2)O(3) nanocomposite catal...

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Detalles Bibliográficos
Autores principales:	Hernandez R., Rafael A., Burchell-Reyes, Kelly, Braga, Arthur P. C. A., Lopez, Jennifer Keough, Forgione, Pat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981965/ https://www.ncbi.nlm.nih.gov/pubmed/35424611 http://dx.doi.org/10.1039/d1ra08443g

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