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PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an accumulation of cells in G2-M phase. Moreover...

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Detalles Bibliográficos
Autores principales:	Ohba, Shigeo, Tang, Yongjian, Johannessen, Tor-Christian Aase, Mukherjee, Joydeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981990/ https://www.ncbi.nlm.nih.gov/pubmed/35392228 http://dx.doi.org/10.3389/fonc.2022.844861

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