Blocking key mutated hotspot residues in the RBD of the omicron variant (B.1.1.529) with medicinal compounds to disrupt the RBD-hACE2 complex using molecular screening and simulation approaches

A new variant of SARS-CoV-2 known as the omicron variant (B.1.1.529) reported in South Africa with 30 mutations in the whole spike protein, among which 15 mutations are in the receptor-binding domain, is continuously spreading exponentially around the world. The omicron variant is reported to be hig...

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Detalles Bibliográficos
Autores principales: Khan, Abbas, Randhawa, AsfandYar Waheed, Balouch, Ali Raza, Mukhtar, Naila, Sayaf, Abrar Mohammad, Suleman, Muhammad, Khan, Taimoor, Ali, Shahid, Ali, Syed Shujait, Wang, Yanjing, Mohammad, Anwar, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982251/
https://www.ncbi.nlm.nih.gov/pubmed/35424688
http://dx.doi.org/10.1039/d2ra00277a

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