Cargando…

Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells

Malignant pleural mesothelioma (MPM) is a rare type of cancer with a grim prognosis. So far, no targetable oncogenic mutation was identified in MPM and biomarkers with predictive value toward drug sensitivity or resistance are also lacking. Nintedanib (BIBF1120) is a small-molecule tyrosine kinase i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hegedüs, Luca, Szücs, Kata D., Kudla, Matthias, Heidenreich, Julian, Jendrossek, Verena, Peña-Llopis, Samuel, Garay, Tamas, Czirok, Andras, Aigner, Clemens, Plönes, Till, Vega-Rubin-de-Celis, Silvia, Hegedüs, Balazs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982261/ https://www.ncbi.nlm.nih.gov/pubmed/35392170 http://dx.doi.org/10.3389/fcell.2022.852812

Ejemplares similares

Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations
por: Rittler, Dominika, et al.
Publicado: (2020)

The role of Allee effect in modelling post resection recurrence of glioblastoma
por: Neufeld, Zoltan, et al.
Publicado: (2017)

The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb
por: Rittler, Dominika, et al.
Publicado: (2019)

A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis
por: Niersch, Jennifer, et al.
Publicado: (2021)

HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line
por: Hegedűs, Luca, et al.
Publicado: (2020)

Prognostic Factors for Leiomyosarcoma with Isolated Metastases to the Lungs: Impact of Metastasectomy
por: Stork, Theresa, et al.
Publicado: (2022)

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
por: Molnár, Eszter, et al.
Publicado: (2018)

Malignant Pleural Mesothelioma (MPM) Presenting as Hydropneumothorax
por: Kuramochi, Masami, et al.
Publicado: (2023)

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter
por: László, Laura, et al.
Publicado: (2016)

HDAC Inhibition Induces Cell Cycle Arrest and Mesenchymal-Epithelial Transition in a Novel Pleural-Effusion Derived Uterine Carcinosarcoma Cell Line
por: Stockhammer, Paul, et al.
Publicado: (2021)

Dataset of a study investigating autologous blood patch pleurodesis in postoperative prolonged air leaks after lung resection
por: Ploenes, Till, et al.
Publicado: (2020)

Insights into immunometabolism: A dataset correlating the (18)FDG PET/CT maximum standard uptake value of the primary tumor with the CCL18 serum level in non-small cell lung cancer
por: Dönmez, Tugba, et al.
Publicado: (2021)

Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK
por: Hegedüs, Luca, et al.
Publicado: (2017)

Simplified approach to ICU severity scoring with MPM and EUROSCORE
por: Reeves, JH, et al.
Publicado: (2010)

Preliminary update of the Mortality Probability Model (MPM0)
por: Higgins, T, et al.
Publicado: (2005)

A Novel Panel of Serum Biomarkers for MPM Diagnosis
por: Bonotti, A., et al.
Publicado: (2017)

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation
por: Hegedüs, Luca, et al.
Publicado: (2021)

Why do horseflies need polarization vision for host detection? Polarization helps tabanid flies to select sunlit dark host animals from the dark patches of the visual environment
por: Horváth, Gábor, et al.
Publicado: (2017)

ABCMdb reloaded: updates on mutations in ATP binding cassette proteins
por: Tordai, Hedvig, et al.
Publicado: (2017)

Implementation of an experimental isolated lung perfusion model on surgically resected human lobes
por: Slama, Alexis, et al.
Publicado: (2019)

OPETH: Open Source Solution for Real-Time Peri-Event Time Histogram Based on Open Ephys
por: Széll, András, et al.
Publicado: (2020)

Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells
por: Tátrai, Enikő, et al.
Publicado: (2017)

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis
por: Filkor, Kata, et al.
Publicado: (2013)

Multicellular contractility contributes to the emergence of mesothelioma nodules
por: Tarnoki-Zach, Julia, et al.
Publicado: (2020)

Minimal-invasive approach reduces cardiopulmonary complications in elderly after lung cancer surgery
por: Zaatar, Mohamed, et al.
Publicado: (2020)

MTA1 promotes metastasis of MPM via suppression of E-cadherin
por: Xu, Caihua, et al.
Publicado: (2015)

Immunomodulatory germline variation associated with the development of multiple primary melanoma (MPM)
por: Ferguson, Robert, et al.
Publicado: (2019)

Immunotherapy, the promise for present and future of malignant pleural mesothelioma (MPM) treatment
por: Gounant, Valérie, et al.
Publicado: (2021)

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression
por: Molnár, Eszter, et al.
Publicado: (2019)

A Novel Mathematical Model Describing Adaptive Cellular Drug Metabolism and Toxicity in the Chemoimmune System
por: Tóth, Attila, et al.
Publicado: (2015)

Open Source Tools for Temporally Controlled Rodent Behavior Suitable for Electrophysiology and Optogenetic Manipulations
por: Solari, Nicola, et al.
Publicado: (2018)

Socialismo y burocracia
por: Hegedüs, András, 1922-1999
Publicado: (1979)

Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition
por: Ghanim, Bahil, et al.
Publicado: (2020)

Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases
por: Vega-Rubín-de-Celis, Silvia, et al.
Publicado: (2020)

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop
por: Mózner, Orsolya, et al.
Publicado: (2023)

Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM)
por: Klampatsa, Astero, et al.
Publicado: (2017)

Mutational Profile of Malignant Pleural Mesothelioma (MPM) in the Phase II RAMES Study
por: Pagano, Maria, et al.
Publicado: (2020)

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy
por: Hegedűs, Krisztina, et al.
Publicado: (2016)

Stereoselective synthesis of trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety
por: Varró, Gábor, et al.
Publicado: (2018)

The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations
por: Nagy, Tamás, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vhbe4s203g715u2mfcosja3e5d