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Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry
As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hos...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982302/ https://www.ncbi.nlm.nih.gov/pubmed/35380371 http://dx.doi.org/10.1007/s40615-022-01277-8 |
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author | Shah, Kevin S. Reyes-Miranda, Adriana E. Bradley, Steven M. Breathett, Khadijah Das, Sandeep R. Gluckman, Ty J. Gupta, Divya Leung, Daniel T. Mutharasan, R. Kannan Peterson, Pamela N. Spivak, Emily S. Shah, Rashmee U. |
author_facet | Shah, Kevin S. Reyes-Miranda, Adriana E. Bradley, Steven M. Breathett, Khadijah Das, Sandeep R. Gluckman, Ty J. Gupta, Divya Leung, Daniel T. Mutharasan, R. Kannan Peterson, Pamela N. Spivak, Emily S. Shah, Rashmee U. |
author_sort | Shah, Kevin S. |
collection | PubMed |
description | As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association’s COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated. |
format | Online Article Text |
id | pubmed-8982302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89823022022-04-06 Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry Shah, Kevin S. Reyes-Miranda, Adriana E. Bradley, Steven M. Breathett, Khadijah Das, Sandeep R. Gluckman, Ty J. Gupta, Divya Leung, Daniel T. Mutharasan, R. Kannan Peterson, Pamela N. Spivak, Emily S. Shah, Rashmee U. J Racial Ethn Health Disparities Article As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association’s COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated. Springer International Publishing 2022-04-05 2023 /pmc/articles/PMC8982302/ /pubmed/35380371 http://dx.doi.org/10.1007/s40615-022-01277-8 Text en © W. Montague Cobb-NMA Health Institute 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Shah, Kevin S. Reyes-Miranda, Adriana E. Bradley, Steven M. Breathett, Khadijah Das, Sandeep R. Gluckman, Ty J. Gupta, Divya Leung, Daniel T. Mutharasan, R. Kannan Peterson, Pamela N. Spivak, Emily S. Shah, Rashmee U. Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title | Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title_full | Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title_fullStr | Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title_full_unstemmed | Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title_short | Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association’s Get With The Guidelines Registry |
title_sort | clinical trial participation and covid-19: a descriptive analysis from the american heart association’s get with the guidelines registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982302/ https://www.ncbi.nlm.nih.gov/pubmed/35380371 http://dx.doi.org/10.1007/s40615-022-01277-8 |
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