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The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets

BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccination is usually based on administering periodically PRRS modified live virus (MLV) in sows throughout their life. Using this schedule, transfer of maternally derived antibodies to the offspring is limited. The aim of the...

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Autores principales: Martín‐Valls, Gerard Eduard, Mortensen, Preben, Clilvert, Hepzibar, Li, Yanli, Cortey, Martí, Sno, Melanie, Barna, Timea, Terré, Marisa, Guerra, Nicolas, Mateu, Enric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982505/
https://www.ncbi.nlm.nih.gov/pubmed/35414939
http://dx.doi.org/10.1002/vro2.34
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author Martín‐Valls, Gerard Eduard
Mortensen, Preben
Clilvert, Hepzibar
Li, Yanli
Cortey, Martí
Sno, Melanie
Barna, Timea
Terré, Marisa
Guerra, Nicolas
Mateu, Enric
author_facet Martín‐Valls, Gerard Eduard
Mortensen, Preben
Clilvert, Hepzibar
Li, Yanli
Cortey, Martí
Sno, Melanie
Barna, Timea
Terré, Marisa
Guerra, Nicolas
Mateu, Enric
author_sort Martín‐Valls, Gerard Eduard
collection PubMed
description BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccination is usually based on administering periodically PRRS modified live virus (MLV) in sows throughout their life. Using this schedule, transfer of maternally derived antibodies to the offspring is limited. The aim of the present study was to test the concept of priming with an MLV and boosting with a commercial inactivated virus vaccine in sows to reduce PRRSV incidence and improve productivity. METHODS: On two farms, all the sows were vaccinated with a MLV vaccine at week 8 of gestation. Then two groups were designated, one group was re‐vaccinated in the third week prior to farrowing and using a commercial inactivated vaccine (the PG group). The second group was the control group (C). Assays for PRRSV infection and productive parameters were evaluated. RESULTS: For both farms, the incidence of PRRSV was lower at 6 weeks of age in PG than in C (p < 0.05). At weaning the proportion of PRRSV seropositive piglets was higher for PG as well (p < 0.05). The litters from C sows from both farms showed a higher pre‐weaning mortality (odds ratio, C vs. PG = 1.18 ± 0.09; p < 0.05). CONCLUSIONS: Administration of the vaccine in sows before farrowing was safe and associated with reduced incidence of PRRSV in piglets up to 6 weeks of age.
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spelling pubmed-89825052022-04-11 The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets Martín‐Valls, Gerard Eduard Mortensen, Preben Clilvert, Hepzibar Li, Yanli Cortey, Martí Sno, Melanie Barna, Timea Terré, Marisa Guerra, Nicolas Mateu, Enric Vet Rec Open Original Research BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccination is usually based on administering periodically PRRS modified live virus (MLV) in sows throughout their life. Using this schedule, transfer of maternally derived antibodies to the offspring is limited. The aim of the present study was to test the concept of priming with an MLV and boosting with a commercial inactivated virus vaccine in sows to reduce PRRSV incidence and improve productivity. METHODS: On two farms, all the sows were vaccinated with a MLV vaccine at week 8 of gestation. Then two groups were designated, one group was re‐vaccinated in the third week prior to farrowing and using a commercial inactivated vaccine (the PG group). The second group was the control group (C). Assays for PRRSV infection and productive parameters were evaluated. RESULTS: For both farms, the incidence of PRRSV was lower at 6 weeks of age in PG than in C (p < 0.05). At weaning the proportion of PRRSV seropositive piglets was higher for PG as well (p < 0.05). The litters from C sows from both farms showed a higher pre‐weaning mortality (odds ratio, C vs. PG = 1.18 ± 0.09; p < 0.05). CONCLUSIONS: Administration of the vaccine in sows before farrowing was safe and associated with reduced incidence of PRRSV in piglets up to 6 weeks of age. John Wiley and Sons Inc. 2022-04-05 /pmc/articles/PMC8982505/ /pubmed/35414939 http://dx.doi.org/10.1002/vro2.34 Text en © 2022 The Authors. Veterinary Record Open published by John Wiley & Sons Ltd on behalf of British Veterinary Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Martín‐Valls, Gerard Eduard
Mortensen, Preben
Clilvert, Hepzibar
Li, Yanli
Cortey, Martí
Sno, Melanie
Barna, Timea
Terré, Marisa
Guerra, Nicolas
Mateu, Enric
The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title_full The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title_fullStr The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title_full_unstemmed The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title_short The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets
title_sort use of a whole inactivated prrs virus vaccine administered in sows and impact on maternally derived immunity and timing of prrs virus infection in piglets
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982505/
https://www.ncbi.nlm.nih.gov/pubmed/35414939
http://dx.doi.org/10.1002/vro2.34
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