Cargando…

Protective HLA alleles against severe COVID-19: HLA-A*68 as an ancestral protection allele in Tapachula-Chiapas, Mexico

HLA is a polymorphic antigen presenter which has provided valuable information on the susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific susceptibility or resistance alleles to severe COVID-19 in an ethnically dependent manner. This pilot study investigated HLA...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernández-Doño, Susana, Sánchez-González, Roberto Alejandro, Trujillo-Vizuet, Ma Guadalupe, Zamudio-Castellanos, Fabiola Yeseline, García-Silva, Rafael, Bulos-Rodríguez, Pedro, Vazquez-Guzmán, Carlos A., Cárdenas-Ramos, Ximena, de León Rodríguez, Diana, Elías, Fabiola, Domínguez-Arrevillaga, Sergio, Pérez-Tirado, José Manuel, Vera-Lastra, Olga Lidia, Granados, Julio, Sepúlveda-Delgado, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982524/
https://www.ncbi.nlm.nih.gov/pubmed/35395388
http://dx.doi.org/10.1016/j.clim.2022.108990
Descripción
Sumario:HLA is a polymorphic antigen presenter which has provided valuable information on the susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific susceptibility or resistance alleles to severe COVID-19 in an ethnically dependent manner. This pilot study investigated HLA alleles associated with COVID-19 severity in Tapachula, Chiapas, Mexico. A total of 146 Mexican Mestizos were typed for HLA class I and II using PCR-SSP. The patients were classified according to the outcome (death or improvement) and the infection's severity (mild or severe). In addition, a group of exposed uninfected individuals was included. HLA-A*68 was found to be a protective allele against the severe infection and fatal outcome; pC = 0.03, OR = 0.4, 95% CI =0.20–0.86, and pC =0.009, OR = 0.3, 95% CI =0.13–0.71 respectively. HLA-DRB1*03 also appears to be a protective factor against fatal outcome pC = 0.009, OR = 0.1, 95%IC = 0.01–0.66; however, the low frequency of this allele in the studied population limits the statistical power. The severity and fatal outcome of COVID-19 patients in Tapachula, Chiapas depend more on the lack of resistance than susceptibility HLA alleles.