Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a specific rat monoclonal IgG2α antibody, 4D7, directed against the common s...

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Detalles Bibliográficos
Autores principales: Tvorogov, Denis, Thompson‐Peach, Chloe A L, Foßelteder, Johannes, Dottore, Mara, Stomski, Frank, Onnesha, Suraiya A, Lim, Kelly, Moretti, Paul A B, Pitson, Stuart M, Ross, David M, Reinisch, Andreas, Thomas, Daniel, Lopez, Angel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982588/
https://www.ncbi.nlm.nih.gov/pubmed/35156745
http://dx.doi.org/10.15252/embr.202152904

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