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Infantile hepatic hemangiomas: looking backwards and forwards
Infantile hepatic hemangiomas (IHHs) are common benign tumors seen in the liver of infants. IHHs are true infantile hemangiomas (IHs) and have phases of proliferation and involution parallel to those of cutaneous IHs. The definition and classification of IHH are still confusing in the literature. Th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982613/ https://www.ncbi.nlm.nih.gov/pubmed/35692445 http://dx.doi.org/10.1093/pcmedi/pbac006 |
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author | Gong, Xue Li, Yanan Yang, Kaiying Chen, Siyuan Ji, Yi |
author_facet | Gong, Xue Li, Yanan Yang, Kaiying Chen, Siyuan Ji, Yi |
author_sort | Gong, Xue |
collection | PubMed |
description | Infantile hepatic hemangiomas (IHHs) are common benign tumors seen in the liver of infants. IHHs are true infantile hemangiomas (IHs) and have phases of proliferation and involution parallel to those of cutaneous IHs. The definition and classification of IHH are still confusing in the literature. The mechanisms during the pathogenesis of IHH have yet to be discovered. The clinical manifestations of IHH are heterogeneous. Although most IHH lesions are asymptomatic, some lesions can lead to severe complications, such as hypothyroidism, consumptive coagulopathy, and high-output congestive cardiac failure. Consequently, some patients can possibly encounter a fatal clinical condition. The heterogeneity of the lesions and the occurrence of disease-related comorbidities can make the treatment of IHH challenging. Oral propranolol is emerging as an effective systemic approach to IHH with obvious responses in tumor remission and symptom regression. However, the precise clinical characteristics and treatment strategies for patients with severe IHH have not yet been well established. Here, we summarize the epidemiology, pathogenic mechanism, clinical manifestations, diagnosis, and treatment of IHH. Recent updates and future perspectives for IHH will also be elaborated. |
format | Online Article Text |
id | pubmed-8982613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89826132022-06-10 Infantile hepatic hemangiomas: looking backwards and forwards Gong, Xue Li, Yanan Yang, Kaiying Chen, Siyuan Ji, Yi Precis Clin Med Review Infantile hepatic hemangiomas (IHHs) are common benign tumors seen in the liver of infants. IHHs are true infantile hemangiomas (IHs) and have phases of proliferation and involution parallel to those of cutaneous IHs. The definition and classification of IHH are still confusing in the literature. The mechanisms during the pathogenesis of IHH have yet to be discovered. The clinical manifestations of IHH are heterogeneous. Although most IHH lesions are asymptomatic, some lesions can lead to severe complications, such as hypothyroidism, consumptive coagulopathy, and high-output congestive cardiac failure. Consequently, some patients can possibly encounter a fatal clinical condition. The heterogeneity of the lesions and the occurrence of disease-related comorbidities can make the treatment of IHH challenging. Oral propranolol is emerging as an effective systemic approach to IHH with obvious responses in tumor remission and symptom regression. However, the precise clinical characteristics and treatment strategies for patients with severe IHH have not yet been well established. Here, we summarize the epidemiology, pathogenic mechanism, clinical manifestations, diagnosis, and treatment of IHH. Recent updates and future perspectives for IHH will also be elaborated. Oxford University Press 2022-02-11 /pmc/articles/PMC8982613/ /pubmed/35692445 http://dx.doi.org/10.1093/pcmedi/pbac006 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Gong, Xue Li, Yanan Yang, Kaiying Chen, Siyuan Ji, Yi Infantile hepatic hemangiomas: looking backwards and forwards |
title | Infantile hepatic hemangiomas: looking backwards and forwards |
title_full | Infantile hepatic hemangiomas: looking backwards and forwards |
title_fullStr | Infantile hepatic hemangiomas: looking backwards and forwards |
title_full_unstemmed | Infantile hepatic hemangiomas: looking backwards and forwards |
title_short | Infantile hepatic hemangiomas: looking backwards and forwards |
title_sort | infantile hepatic hemangiomas: looking backwards and forwards |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982613/ https://www.ncbi.nlm.nih.gov/pubmed/35692445 http://dx.doi.org/10.1093/pcmedi/pbac006 |
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