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Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak

Continuous appearance of SARS-CoV-2 variants and mass vaccination have been intricately influencing on the COVID-19 situation. To elucidate the current status in Japan, we analyzed totally 2,000 sera in August (n = 1,000) and December (n = 1,000) 2021 collected from individuals who underwent a healt...

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Autores principales: Ren, Zhenxiao, Nishimura, Mitsuhiro, Tjan, Lidya Handayani, Furukawa, Koichi, Kurahashi, Yukiya, Sutandhio, Silvia, Aoki, Kaito, Hasegawa, Natsumi, Arii, Jun, Uto, Kenichi, Matsui, Keiji, Sato, Itsuko, Saegusa, Jun, Godai, Nonoka, Takeshita, Kohei, Yamamoto, Masaki, Nagashima, Tatsuya, Mori, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982849/
https://www.ncbi.nlm.nih.gov/pubmed/35381036
http://dx.doi.org/10.1371/journal.pone.0266270
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author Ren, Zhenxiao
Nishimura, Mitsuhiro
Tjan, Lidya Handayani
Furukawa, Koichi
Kurahashi, Yukiya
Sutandhio, Silvia
Aoki, Kaito
Hasegawa, Natsumi
Arii, Jun
Uto, Kenichi
Matsui, Keiji
Sato, Itsuko
Saegusa, Jun
Godai, Nonoka
Takeshita, Kohei
Yamamoto, Masaki
Nagashima, Tatsuya
Mori, Yasuko
author_facet Ren, Zhenxiao
Nishimura, Mitsuhiro
Tjan, Lidya Handayani
Furukawa, Koichi
Kurahashi, Yukiya
Sutandhio, Silvia
Aoki, Kaito
Hasegawa, Natsumi
Arii, Jun
Uto, Kenichi
Matsui, Keiji
Sato, Itsuko
Saegusa, Jun
Godai, Nonoka
Takeshita, Kohei
Yamamoto, Masaki
Nagashima, Tatsuya
Mori, Yasuko
author_sort Ren, Zhenxiao
collection PubMed
description Continuous appearance of SARS-CoV-2 variants and mass vaccination have been intricately influencing on the COVID-19 situation. To elucidate the current status in Japan, we analyzed totally 2,000 sera in August (n = 1,000) and December (n = 1,000) 2021 collected from individuals who underwent a health check-up. The anti-N seropositive rate were 2.1% and 3.9% in August and December 2021, respectively, demonstrating a Delta variant endemic during that time; it was approximately twofold higher than the rate based on the PCR-based diagnosis. The anti-S seropositive rate was 38.7% in August and it reached 90.8% in December, in concordance with the vaccination rate in Japan. In the December cohort, 78.7% of the sera showed neutralizing activity against the Delta variant, whereas that against the Omicron was much lower at 36.6%. These analyses revealed that effective immunity against the Delta variant was established in December 2021, however, prompt three-dose vaccination is needed to overcome Omicron’s outbreak.
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spelling pubmed-89828492022-04-06 Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak Ren, Zhenxiao Nishimura, Mitsuhiro Tjan, Lidya Handayani Furukawa, Koichi Kurahashi, Yukiya Sutandhio, Silvia Aoki, Kaito Hasegawa, Natsumi Arii, Jun Uto, Kenichi Matsui, Keiji Sato, Itsuko Saegusa, Jun Godai, Nonoka Takeshita, Kohei Yamamoto, Masaki Nagashima, Tatsuya Mori, Yasuko PLoS One Research Article Continuous appearance of SARS-CoV-2 variants and mass vaccination have been intricately influencing on the COVID-19 situation. To elucidate the current status in Japan, we analyzed totally 2,000 sera in August (n = 1,000) and December (n = 1,000) 2021 collected from individuals who underwent a health check-up. The anti-N seropositive rate were 2.1% and 3.9% in August and December 2021, respectively, demonstrating a Delta variant endemic during that time; it was approximately twofold higher than the rate based on the PCR-based diagnosis. The anti-S seropositive rate was 38.7% in August and it reached 90.8% in December, in concordance with the vaccination rate in Japan. In the December cohort, 78.7% of the sera showed neutralizing activity against the Delta variant, whereas that against the Omicron was much lower at 36.6%. These analyses revealed that effective immunity against the Delta variant was established in December 2021, however, prompt three-dose vaccination is needed to overcome Omicron’s outbreak. Public Library of Science 2022-04-05 /pmc/articles/PMC8982849/ /pubmed/35381036 http://dx.doi.org/10.1371/journal.pone.0266270 Text en © 2022 Ren et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ren, Zhenxiao
Nishimura, Mitsuhiro
Tjan, Lidya Handayani
Furukawa, Koichi
Kurahashi, Yukiya
Sutandhio, Silvia
Aoki, Kaito
Hasegawa, Natsumi
Arii, Jun
Uto, Kenichi
Matsui, Keiji
Sato, Itsuko
Saegusa, Jun
Godai, Nonoka
Takeshita, Kohei
Yamamoto, Masaki
Nagashima, Tatsuya
Mori, Yasuko
Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title_full Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title_fullStr Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title_full_unstemmed Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title_short Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
title_sort large-scale serosurveillance of covid-19 in japan: acquisition of neutralizing antibodies for delta but not for omicron and requirement of booster vaccination to overcome the omicron’s outbreak
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982849/
https://www.ncbi.nlm.nih.gov/pubmed/35381036
http://dx.doi.org/10.1371/journal.pone.0266270
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