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Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma

Isocitrate dehydrogenase (IDH) mutations in low-grade gliomas (LGG) result in improved survival and DNA hypermethylation compared with IDH wild-type LGGs. IDH-mutant LGGs become hypomethylated during progression. It is uncertain whether methylation changes occur during IDH wild-type GBM progression...

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Detalles Bibliográficos
Autores principales:	Salas, Lucas A., Stewart, Thomas G., Mobley, Bret C., Peng, Chengwei, Liu, Jing, Loganathan, Sudan N., Wang, Jialiang, Ma, Yanjun, Berger, Mitchel S., Absher, Devin, Hu, Yang, Moots, Paul L., Christensen, Brock C., Clark, Stephen W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983000/ https://www.ncbi.nlm.nih.gov/pubmed/35392283 http://dx.doi.org/10.1158/2767-9764.CRC-21-0088

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