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Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983001/ https://www.ncbi.nlm.nih.gov/pubmed/35415208 http://dx.doi.org/10.1002/trc2.12269 |
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author | Ponirakis, Georgios Hamad, Hanadi Al Khan, Adnan Petropoulos, Ioannis N. Gad, Hoda Chandran, Mani Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Arasn, Anjum Manikoth, Pravija Abdelrahim, Yasmin H.M. Refaee, Mahmoud A Thodi, Noushad Vattoth, Surjith Almuhannadi, Hamad Mahfoud, Ziyad R. Bhat, Harun Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. |
author_facet | Ponirakis, Georgios Hamad, Hanadi Al Khan, Adnan Petropoulos, Ioannis N. Gad, Hoda Chandran, Mani Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Arasn, Anjum Manikoth, Pravija Abdelrahim, Yasmin H.M. Refaee, Mahmoud A Thodi, Noushad Vattoth, Surjith Almuhannadi, Hamad Mahfoud, Ziyad R. Bhat, Harun Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. |
author_sort | Ponirakis, Georgios |
collection | PubMed |
description | INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI, and dementia underwent assessment of Montreal Cognitive Assessment (MoCA), MRI brain volumetry, and CCM. RESULTS: Two hundred eight participants with NCI (n = 42), MCI (n = 98), and dementia (n = 68) of comparable age and gender were studied. For MCI, the area under the curve (AUC) of CCM (76% to 81%), was higher than brain volumetry (52% to 70%). For dementia, the AUC of CCM (77% to 85%), was comparable to brain volumetry (69% to 93%). Corneal nerve fiber density, length, branch density, whole brain, hippocampus, cortical gray matter, thalamus, amygdala, and ventricle volumes were associated with cognitive impairment after adjustment for confounders (All P’s < .01). DISCUSSION: The diagnostic capability of CCM compared to brain volumetry is higher for identifying MCI and comparable for dementia, and abnormalities in both modalities are associated with cognitive impairment. |
format | Online Article Text |
id | pubmed-8983001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89830012022-04-11 Loss of corneal nerves and brain volume in mild cognitive impairment and dementia Ponirakis, Georgios Hamad, Hanadi Al Khan, Adnan Petropoulos, Ioannis N. Gad, Hoda Chandran, Mani Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Arasn, Anjum Manikoth, Pravija Abdelrahim, Yasmin H.M. Refaee, Mahmoud A Thodi, Noushad Vattoth, Surjith Almuhannadi, Hamad Mahfoud, Ziyad R. Bhat, Harun Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Alzheimers Dement (N Y) Research Articles INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI, and dementia underwent assessment of Montreal Cognitive Assessment (MoCA), MRI brain volumetry, and CCM. RESULTS: Two hundred eight participants with NCI (n = 42), MCI (n = 98), and dementia (n = 68) of comparable age and gender were studied. For MCI, the area under the curve (AUC) of CCM (76% to 81%), was higher than brain volumetry (52% to 70%). For dementia, the AUC of CCM (77% to 85%), was comparable to brain volumetry (69% to 93%). Corneal nerve fiber density, length, branch density, whole brain, hippocampus, cortical gray matter, thalamus, amygdala, and ventricle volumes were associated with cognitive impairment after adjustment for confounders (All P’s < .01). DISCUSSION: The diagnostic capability of CCM compared to brain volumetry is higher for identifying MCI and comparable for dementia, and abnormalities in both modalities are associated with cognitive impairment. John Wiley and Sons Inc. 2022-04-05 /pmc/articles/PMC8983001/ /pubmed/35415208 http://dx.doi.org/10.1002/trc2.12269 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Ponirakis, Georgios Hamad, Hanadi Al Khan, Adnan Petropoulos, Ioannis N. Gad, Hoda Chandran, Mani Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Arasn, Anjum Manikoth, Pravija Abdelrahim, Yasmin H.M. Refaee, Mahmoud A Thodi, Noushad Vattoth, Surjith Almuhannadi, Hamad Mahfoud, Ziyad R. Bhat, Harun Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title | Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title_full | Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title_fullStr | Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title_full_unstemmed | Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title_short | Loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
title_sort | loss of corneal nerves and brain volume in mild cognitive impairment and dementia |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983001/ https://www.ncbi.nlm.nih.gov/pubmed/35415208 http://dx.doi.org/10.1002/trc2.12269 |
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