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Loss of corneal nerves and brain volume in mild cognitive impairment and dementia

INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI,...

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Autores principales: Ponirakis, Georgios, Hamad, Hanadi Al, Khan, Adnan, Petropoulos, Ioannis N., Gad, Hoda, Chandran, Mani, Elsotouhy, Ahmed, Ramadan, Marwan, Gawhale, Priya V., Elorrabi, Marwa, Gadelseed, Masharig, Tosino, Rhia, Arasn, Anjum, Manikoth, Pravija, Abdelrahim, Yasmin H.M., Refaee, Mahmoud A, Thodi, Noushad, Vattoth, Surjith, Almuhannadi, Hamad, Mahfoud, Ziyad R., Bhat, Harun, Own, Ahmed, Shuaib, Ashfaq, Malik, Rayaz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983001/
https://www.ncbi.nlm.nih.gov/pubmed/35415208
http://dx.doi.org/10.1002/trc2.12269
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author Ponirakis, Georgios
Hamad, Hanadi Al
Khan, Adnan
Petropoulos, Ioannis N.
Gad, Hoda
Chandran, Mani
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Gadelseed, Masharig
Tosino, Rhia
Arasn, Anjum
Manikoth, Pravija
Abdelrahim, Yasmin H.M.
Refaee, Mahmoud A
Thodi, Noushad
Vattoth, Surjith
Almuhannadi, Hamad
Mahfoud, Ziyad R.
Bhat, Harun
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
author_facet Ponirakis, Georgios
Hamad, Hanadi Al
Khan, Adnan
Petropoulos, Ioannis N.
Gad, Hoda
Chandran, Mani
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Gadelseed, Masharig
Tosino, Rhia
Arasn, Anjum
Manikoth, Pravija
Abdelrahim, Yasmin H.M.
Refaee, Mahmoud A
Thodi, Noushad
Vattoth, Surjith
Almuhannadi, Hamad
Mahfoud, Ziyad R.
Bhat, Harun
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
author_sort Ponirakis, Georgios
collection PubMed
description INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI, and dementia underwent assessment of Montreal Cognitive Assessment (MoCA), MRI brain volumetry, and CCM. RESULTS: Two hundred eight participants with NCI (n = 42), MCI (n = 98), and dementia (n = 68) of comparable age and gender were studied. For MCI, the area under the curve (AUC) of CCM (76% to 81%), was higher than brain volumetry (52% to 70%). For dementia, the AUC of CCM (77% to 85%), was comparable to brain volumetry (69% to 93%). Corneal nerve fiber density, length, branch density, whole brain, hippocampus, cortical gray matter, thalamus, amygdala, and ventricle volumes were associated with cognitive impairment after adjustment for confounders (All P’s < .01). DISCUSSION: The diagnostic capability of CCM compared to brain volumetry is higher for identifying MCI and comparable for dementia, and abnormalities in both modalities are associated with cognitive impairment.
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spelling pubmed-89830012022-04-11 Loss of corneal nerves and brain volume in mild cognitive impairment and dementia Ponirakis, Georgios Hamad, Hanadi Al Khan, Adnan Petropoulos, Ioannis N. Gad, Hoda Chandran, Mani Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Arasn, Anjum Manikoth, Pravija Abdelrahim, Yasmin H.M. Refaee, Mahmoud A Thodi, Noushad Vattoth, Surjith Almuhannadi, Hamad Mahfoud, Ziyad R. Bhat, Harun Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Alzheimers Dement (N Y) Research Articles INTRODUCTION: This study compared the capability of corneal confocal microscopy (CCM) with magnetic resonance imaging (MRI) brain volumetry for the diagnosis of mild cognitive impairment (MCI) and dementia. METHODS: In this cross‐sectional study, participants with no cognitive impairment (NCI), MCI, and dementia underwent assessment of Montreal Cognitive Assessment (MoCA), MRI brain volumetry, and CCM. RESULTS: Two hundred eight participants with NCI (n = 42), MCI (n = 98), and dementia (n = 68) of comparable age and gender were studied. For MCI, the area under the curve (AUC) of CCM (76% to 81%), was higher than brain volumetry (52% to 70%). For dementia, the AUC of CCM (77% to 85%), was comparable to brain volumetry (69% to 93%). Corneal nerve fiber density, length, branch density, whole brain, hippocampus, cortical gray matter, thalamus, amygdala, and ventricle volumes were associated with cognitive impairment after adjustment for confounders (All P’s < .01). DISCUSSION: The diagnostic capability of CCM compared to brain volumetry is higher for identifying MCI and comparable for dementia, and abnormalities in both modalities are associated with cognitive impairment. John Wiley and Sons Inc. 2022-04-05 /pmc/articles/PMC8983001/ /pubmed/35415208 http://dx.doi.org/10.1002/trc2.12269 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Ponirakis, Georgios
Hamad, Hanadi Al
Khan, Adnan
Petropoulos, Ioannis N.
Gad, Hoda
Chandran, Mani
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Gadelseed, Masharig
Tosino, Rhia
Arasn, Anjum
Manikoth, Pravija
Abdelrahim, Yasmin H.M.
Refaee, Mahmoud A
Thodi, Noushad
Vattoth, Surjith
Almuhannadi, Hamad
Mahfoud, Ziyad R.
Bhat, Harun
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title_full Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title_fullStr Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title_full_unstemmed Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title_short Loss of corneal nerves and brain volume in mild cognitive impairment and dementia
title_sort loss of corneal nerves and brain volume in mild cognitive impairment and dementia
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983001/
https://www.ncbi.nlm.nih.gov/pubmed/35415208
http://dx.doi.org/10.1002/trc2.12269
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