Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden

Colon cancer is one of the leading causes of cancer-related deaths. Microsatellite instability (MSI) or deficient mismatch repair proteins with a high tumor mutation burden (TMB) colon cancer are less responsive to chemotherapy. Targeted therapies based on early next-generation sequencing (NGS) in m...

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Detalles Bibliográficos
Autores principales: Ashish, Sethi, Raj, Moses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983027/
https://www.ncbi.nlm.nih.gov/pubmed/35399448
http://dx.doi.org/10.7759/cureus.22894
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author Ashish, Sethi
Raj, Moses
author_facet Ashish, Sethi
Raj, Moses
author_sort Ashish, Sethi
collection PubMed
description Colon cancer is one of the leading causes of cancer-related deaths. Microsatellite instability (MSI) or deficient mismatch repair proteins with a high tumor mutation burden (TMB) colon cancer are less responsive to chemotherapy. Targeted therapies based on early next-generation sequencing (NGS) in metastatic colon cancer can help significantly in overall prognosis. Here, we report a case of colon cancer that illustrated significant TMB and MSI and responded poorly to treatment due to delay in NGS testing.
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spelling pubmed-89830272022-04-07 Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden Ashish, Sethi Raj, Moses Cureus Internal Medicine Colon cancer is one of the leading causes of cancer-related deaths. Microsatellite instability (MSI) or deficient mismatch repair proteins with a high tumor mutation burden (TMB) colon cancer are less responsive to chemotherapy. Targeted therapies based on early next-generation sequencing (NGS) in metastatic colon cancer can help significantly in overall prognosis. Here, we report a case of colon cancer that illustrated significant TMB and MSI and responded poorly to treatment due to delay in NGS testing. Cureus 2022-03-06 /pmc/articles/PMC8983027/ /pubmed/35399448 http://dx.doi.org/10.7759/cureus.22894 Text en Copyright © 2022, Ashish et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ashish, Sethi
Raj, Moses
Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title_full Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title_fullStr Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title_full_unstemmed Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title_short Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden
title_sort importance of early next-generation sequencing in microsatellite unstable colon cancer with a high tumor mutation burden
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983027/
https://www.ncbi.nlm.nih.gov/pubmed/35399448
http://dx.doi.org/10.7759/cureus.22894
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AT rajmoses importanceofearlynextgenerationsequencinginmicrosatelliteunstablecoloncancerwithahightumormutationburden

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