Ferret models of alpha-1 antitrypsin deficiency develop lung and liver disease

Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease, but the field lacks a large-animal model that allows for longitudinal assessment of pulmonary function. We hypothesized that ferrets would model human AATD-related lung a...

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Detalles Bibliográficos
Autores principales: He, Nan, Liu, Xiaoming, Vegter, Amber R., Evans, T. Idil A., Gray, Jaimie S., Guo, Junfeng, Moll, Shashanna R., Guo, Lydia J., Luo, Meihui, Ma, Ningxia, Sun, Xingshen, Liang, Bo, Yan, Ziying, Feng, Zehua, Qi, Lisi, Joshi, Arnav S., Shahin, Weam, Yi, Yaling, Gibson-Corley, Katherine N., Hoffman, Eric A., Wang, Kai, Mueller, Christian, Engelhardt, John F., Rosen, Bradley H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983124/
https://www.ncbi.nlm.nih.gov/pubmed/35104244
http://dx.doi.org/10.1172/jci.insight.143004

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