Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/reperfusion injury in mice

Following myocardial infarction (MI), elderly patients have a poorer prognosis than younger patients, which may be linked to increased coronary microvessel susceptibility to injury. Interleukin-36 (IL-36), a newly discovered proinflammatory member of the IL-1 superfamily, may mediate this injury, bu...

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Detalles Bibliográficos
Autores principales: El-Awaisi, Juma, Kavanagh, Dean P.J., Rink, Marco R., Weston, Chris J., Drury, Nigel E., Kalia, Neena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983126/
https://www.ncbi.nlm.nih.gov/pubmed/35113814
http://dx.doi.org/10.1172/jci.insight.155236

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