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Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5–positive (Lgr5(+)) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azoxymethane–dextran sulfate sodium (AOM-DSS) colitis...

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Detalles Bibliográficos
Autores principales:	Klingler, Stefan, Hsu, Kuo-Shun, Hua, Guoqiang, Martin, Maria Laura, Adileh, Mohammad, Baslan, Timour, Zhang, Zhigang, Paty, Philip B., Fuks, Zvi, Brown, Anthony M.C., Kolesnick, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983138/ https://www.ncbi.nlm.nih.gov/pubmed/35260534 http://dx.doi.org/10.1172/jci.insight.153793

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