MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler

Malignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nucl...

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Autores principales: Owosho, Adepitan A., Olatunji, Abiodun S., Adejobi, Adewale F., Fatusi, Olawumi A., Okunade, Toluwaniyin, Maddux, Kelly, Shaw, Justin, Summersgill, Kurt F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983249/
https://www.ncbi.nlm.nih.gov/pubmed/35392490
http://dx.doi.org/10.1155/2022/8749836
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author Owosho, Adepitan A.
Olatunji, Abiodun S.
Adejobi, Adewale F.
Fatusi, Olawumi A.
Okunade, Toluwaniyin
Maddux, Kelly
Shaw, Justin
Summersgill, Kurt F.
author_facet Owosho, Adepitan A.
Olatunji, Abiodun S.
Adejobi, Adewale F.
Fatusi, Olawumi A.
Okunade, Toluwaniyin
Maddux, Kelly
Shaw, Justin
Summersgill, Kurt F.
author_sort Owosho, Adepitan A.
collection PubMed
description Malignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nuclei appearing vesicular, pleomorphic, and hyperchromatic with an admixture of mucous cells and cystic spaces within a prominent connective tissue stroma. Immunohistochemically, the epidermoid cells showed cytokeratin 7 and P63 positivity, and mucous cells were positive for mucicarmine. Molecularly, this case was positive for MAML2 rearrangement by FISH. To our knowledge, this is one of the youngest cases of MEC of the parotid gland reported in the English literature.
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spelling pubmed-89832492022-04-06 MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler Owosho, Adepitan A. Olatunji, Abiodun S. Adejobi, Adewale F. Fatusi, Olawumi A. Okunade, Toluwaniyin Maddux, Kelly Shaw, Justin Summersgill, Kurt F. Case Rep Dent Case Report Malignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nuclei appearing vesicular, pleomorphic, and hyperchromatic with an admixture of mucous cells and cystic spaces within a prominent connective tissue stroma. Immunohistochemically, the epidermoid cells showed cytokeratin 7 and P63 positivity, and mucous cells were positive for mucicarmine. Molecularly, this case was positive for MAML2 rearrangement by FISH. To our knowledge, this is one of the youngest cases of MEC of the parotid gland reported in the English literature. Hindawi 2022-03-29 /pmc/articles/PMC8983249/ /pubmed/35392490 http://dx.doi.org/10.1155/2022/8749836 Text en Copyright © 2022 Adepitan A. Owosho et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Owosho, Adepitan A.
Olatunji, Abiodun S.
Adejobi, Adewale F.
Fatusi, Olawumi A.
Okunade, Toluwaniyin
Maddux, Kelly
Shaw, Justin
Summersgill, Kurt F.
MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title_full MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title_fullStr MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title_full_unstemmed MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title_short MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
title_sort maml2-rearranged mucoepidermoid carcinoma of the parotid gland: a report in a 20-month-old toddler
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983249/
https://www.ncbi.nlm.nih.gov/pubmed/35392490
http://dx.doi.org/10.1155/2022/8749836
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