A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis

We report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevate...

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Detalles Bibliográficos
Autores principales: Migita, Rioko, Kimoto, Yasutaka, Hiura, Junki, Okumura, Yuta, Horiuchi, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983253/
https://www.ncbi.nlm.nih.gov/pubmed/35391896
http://dx.doi.org/10.1155/2022/6852189
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author Migita, Rioko
Kimoto, Yasutaka
Hiura, Junki
Okumura, Yuta
Horiuchi, Takahiko
author_facet Migita, Rioko
Kimoto, Yasutaka
Hiura, Junki
Okumura, Yuta
Horiuchi, Takahiko
author_sort Migita, Rioko
collection PubMed
description We report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevated hepatobiliary enzymes, but various tests revealed no signs suggestive of malignancy. He took baricitinib for 2 months followed by tofacitinib for 4 months. After that, he was diagnosed with hepatocellular carcinoma based on imaging findings and elevated tumor markers. This case showed the possibility of a causal relationship between JAK inhibitors and malignancy.
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spelling pubmed-89832532022-04-06 A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis Migita, Rioko Kimoto, Yasutaka Hiura, Junki Okumura, Yuta Horiuchi, Takahiko Case Rep Rheumatol Case Report We report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevated hepatobiliary enzymes, but various tests revealed no signs suggestive of malignancy. He took baricitinib for 2 months followed by tofacitinib for 4 months. After that, he was diagnosed with hepatocellular carcinoma based on imaging findings and elevated tumor markers. This case showed the possibility of a causal relationship between JAK inhibitors and malignancy. Hindawi 2022-03-29 /pmc/articles/PMC8983253/ /pubmed/35391896 http://dx.doi.org/10.1155/2022/6852189 Text en Copyright © 2022 Rioko Migita et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Migita, Rioko
Kimoto, Yasutaka
Hiura, Junki
Okumura, Yuta
Horiuchi, Takahiko
A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title_full A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title_fullStr A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title_full_unstemmed A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title_short A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
title_sort case of rapidly progressing hepatocellular carcinoma after administration of jak inhibitors to treat rheumatoid arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983253/
https://www.ncbi.nlm.nih.gov/pubmed/35391896
http://dx.doi.org/10.1155/2022/6852189
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