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Secretory defects in pediatric osteosarcoma result from downregulation of selective COPII coatomer proteins

Pediatric osteosarcomas (OS) exhibit extensive genomic instability that has complicated the identification of new targeted therapies. We found the vast majority of 108 patient tumor samples and patient-derived xenografts (PDXs), which display an unusually dilated endoplasmic reticulum (ER), have red...

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Detalles Bibliográficos
Autores principales:	Wood, Rachael K., Flory, Ashley R., Mann, Melissa J., Talbot, Lindsay J., Hendershot, Linda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983387/ https://www.ncbi.nlm.nih.gov/pubmed/35402877 http://dx.doi.org/10.1016/j.isci.2022.104100

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