Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Centrosome amplification (CA) has been implicated in the progression of various cancer types. Although studies have shown that overexpression of PLK4 promotes CA, the effect of tumor microenvironment on polo-like kinase 4 (PLK4) regulation is understudied. The aim of this study was to examine the ro...

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Detalles Bibliográficos
Autores principales: Mittal, Karuna, Kaur, Jaspreet, Sharma, Shaligram, Sharma, Nivya, Wei, Guanhao, Choudhary, Ishita, Imhansi-Jacob, Precious, Maganti, Nagini, Pawar, Shrikant, Rida, Padmashree, Toss, Michael S., Aleskandarany, Mohammed, Janssen, Emiel A., Søiland, Håvard, Gupta, Meenakshi. V., Reid, Michelle D., Rakha, Emad A., Aneja, Ritu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
New Horizons in Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983505/
https://www.ncbi.nlm.nih.gov/pubmed/34933912
http://dx.doi.org/10.1158/1541-7786.MCR-20-0798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983505/
https://www.ncbi.nlm.nih.gov/pubmed/34933912
http://dx.doi.org/10.1158/1541-7786.MCR-20-0798

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