Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer growth. Molecular delineation and targeting of such malignant-cell nonautonomous pathways may help overcome resistance to targeted therapies. Herein we leverage genetic mouse models, patient-derived xenografts,...

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Detalles Bibliográficos
Autores principales: Galán-Díez, Marta, Borot, Florence, Ali, Abdullah Mahmood, Zhao, Junfei, Gil-Iturbe, Eva, Shan, Xiaochuan, Luo, Na, Liu, Yongfeng, Huang, Xi-Ping, Bisikirska, Brygida, Labella, Rossella, Kurland, Irwin, Roth, Bryan L., Quick, Matthias, Mukherjee, Siddhartha, Rabadán, Raul, Carroll, Martin, Raza, Azra, Kousteni, Stavroula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983599/
https://www.ncbi.nlm.nih.gov/pubmed/35046097
http://dx.doi.org/10.1158/2159-8290.CD-21-0692

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