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Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings and histopathological results in immunocompetent and immunocompromised patients. The clinical data of 68 patients wi...

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Autores principales: Wang, Dong-xu, Zhang, Qing, Wen, Qiu-ting, Ding, Guo-xu, Wang, Yu-guang, Du, Feng-xia, Zhang, Tian-yu, Zheng, Xiao-yang, Cong, Hou-yi, Du, You-li, Sang, Jun-zhi, Wang, Ming-da, Zhang, Shan-xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983692/
https://www.ncbi.nlm.nih.gov/pubmed/35383254
http://dx.doi.org/10.1038/s41598-022-09794-6
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author Wang, Dong-xu
Zhang, Qing
Wen, Qiu-ting
Ding, Guo-xu
Wang, Yu-guang
Du, Feng-xia
Zhang, Tian-yu
Zheng, Xiao-yang
Cong, Hou-yi
Du, You-li
Sang, Jun-zhi
Wang, Ming-da
Zhang, Shan-xin
author_facet Wang, Dong-xu
Zhang, Qing
Wen, Qiu-ting
Ding, Guo-xu
Wang, Yu-guang
Du, Feng-xia
Zhang, Tian-yu
Zheng, Xiao-yang
Cong, Hou-yi
Du, You-li
Sang, Jun-zhi
Wang, Ming-da
Zhang, Shan-xin
author_sort Wang, Dong-xu
collection PubMed
description Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings and histopathological results in immunocompetent and immunocompromised patients. The clinical data of 68 patients with PC were collected retrospectively and divided into the immunocompetent group and immunocompromised group. The clinical characteristics, CT manifestations and histopathological characteristics of the two groups of patients were compared. Forty-two patients (61.8%) were immunocompetent, and 26 patients (38.2%) were immunocompromised. Compared with immunocompromised patients, 57.14% (24/42) of immunocompetent patients were asymptomatic (p = 0.002). Compared with immunocompetent patients, cough (14/26, 53.9%) and fever (13/26, 50.0%) were the main symptoms in immunocompromised patients (p = 0.044, p = 0.007). Nodular lesions (97.6%, 41/42) were the most common CT type in immunocompetent patients, and the CT characteristic was a single lesion (25/42, 59.5%); the main histopathological type was nodular fibrogranuloma (30/42, 71.4%), and the main histopathological characteristic was inflammatory granuloma (31/42, 73.81%) formed by macrophage phagocytosis of Cryptococcus. Consolidation (15/26, 57.7%) was more common in the CT type of immunocompromised patients. Multiple lesions (24/26, 92.31%), air bronchial signs (19/26, 73.081%) and cavities (9/26, 34.62%) were the main CT characteristics. The mucinous colloid type (19/26, 73.1%) was its main histopathological type, which was mainly characterized by a small amount of surrounding inflammatory cell infiltration (17/26, 65.4%). There were significant differences in the classification and characteristics of CT and pathology between the two groups (p < 0.05). Through the CT manifestations and histopathological characteristics of PC under different immune function states, it was found that immune function has a significant impact on the CT manifestations and histopathological characteristics of patients with PC.
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spelling pubmed-89836922022-04-06 Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients Wang, Dong-xu Zhang, Qing Wen, Qiu-ting Ding, Guo-xu Wang, Yu-guang Du, Feng-xia Zhang, Tian-yu Zheng, Xiao-yang Cong, Hou-yi Du, You-li Sang, Jun-zhi Wang, Ming-da Zhang, Shan-xin Sci Rep Article Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings and histopathological results in immunocompetent and immunocompromised patients. The clinical data of 68 patients with PC were collected retrospectively and divided into the immunocompetent group and immunocompromised group. The clinical characteristics, CT manifestations and histopathological characteristics of the two groups of patients were compared. Forty-two patients (61.8%) were immunocompetent, and 26 patients (38.2%) were immunocompromised. Compared with immunocompromised patients, 57.14% (24/42) of immunocompetent patients were asymptomatic (p = 0.002). Compared with immunocompetent patients, cough (14/26, 53.9%) and fever (13/26, 50.0%) were the main symptoms in immunocompromised patients (p = 0.044, p = 0.007). Nodular lesions (97.6%, 41/42) were the most common CT type in immunocompetent patients, and the CT characteristic was a single lesion (25/42, 59.5%); the main histopathological type was nodular fibrogranuloma (30/42, 71.4%), and the main histopathological characteristic was inflammatory granuloma (31/42, 73.81%) formed by macrophage phagocytosis of Cryptococcus. Consolidation (15/26, 57.7%) was more common in the CT type of immunocompromised patients. Multiple lesions (24/26, 92.31%), air bronchial signs (19/26, 73.081%) and cavities (9/26, 34.62%) were the main CT characteristics. The mucinous colloid type (19/26, 73.1%) was its main histopathological type, which was mainly characterized by a small amount of surrounding inflammatory cell infiltration (17/26, 65.4%). There were significant differences in the classification and characteristics of CT and pathology between the two groups (p < 0.05). Through the CT manifestations and histopathological characteristics of PC under different immune function states, it was found that immune function has a significant impact on the CT manifestations and histopathological characteristics of patients with PC. Nature Publishing Group UK 2022-04-05 /pmc/articles/PMC8983692/ /pubmed/35383254 http://dx.doi.org/10.1038/s41598-022-09794-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Dong-xu
Zhang, Qing
Wen, Qiu-ting
Ding, Guo-xu
Wang, Yu-guang
Du, Feng-xia
Zhang, Tian-yu
Zheng, Xiao-yang
Cong, Hou-yi
Du, You-li
Sang, Jun-zhi
Wang, Ming-da
Zhang, Shan-xin
Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title_full Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title_fullStr Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title_full_unstemmed Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title_short Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
title_sort comparison of ct findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983692/
https://www.ncbi.nlm.nih.gov/pubmed/35383254
http://dx.doi.org/10.1038/s41598-022-09794-6
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