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Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen
This study aimed to describe the clinical characteristics of age-related macular degeneration (AMD) eyes with both cuticular drusen (CD) and reticular pseudodrusen (RPD). Clinical records of patients diagnosed with CD or RPD with multimodal imaging was reviewed for patients diagnosed with both CD an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983695/ https://www.ncbi.nlm.nih.gov/pubmed/35383241 http://dx.doi.org/10.1038/s41598-022-09608-9 |
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author | Yoon, Je Moon Shin, Dong Hoon Kong, Mingui Ham, Don-Il |
author_facet | Yoon, Je Moon Shin, Dong Hoon Kong, Mingui Ham, Don-Il |
author_sort | Yoon, Je Moon |
collection | PubMed |
description | This study aimed to describe the clinical characteristics of age-related macular degeneration (AMD) eyes with both cuticular drusen (CD) and reticular pseudodrusen (RPD). Clinical records of patients diagnosed with CD or RPD with multimodal imaging was reviewed for patients diagnosed with both CD and RPD. The distribution patterns of CD (macular and diffuse type) and RPD (localized, intermediate, and diffuse type), presence of soft drusen, large drusen (> 200 µm), variant subretinal drusenoid deposits, and macular complications were investigated. Of the 220 eyes of 110 patients diagnosed with CD and 926 eyes of 463 patients diagnosed with RPD, 13 eyes of seven patients met the diagnostic criteria for both CD and RPD. The mean age at initial presentation was 71.4 ± 8.8 years and six patients were female. The mean subfoveal choroidal thickness was 143.8 ± 25.1 µm. The distribution of CD was of the macular type in all eyes. Distribution of RPD was localized in 11 eyes (84.6%) and intermediate in two eyes (15.4%). Soft drusen, large drusen, and variant subretinal drusenoid deposits were present in 13 (100%), 12 (92.3%) and, seven (53.8%) eyes, respectively. Macular neovascularization was observed in two eyes (15.4%). CD and RPD can coexist in eyes with AMD. Multimodal imaging should be used for AMD eyes with features suggestive of CD and RPD, considering the high likelihood of developing late AMD. |
format | Online Article Text |
id | pubmed-8983695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89836952022-04-06 Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen Yoon, Je Moon Shin, Dong Hoon Kong, Mingui Ham, Don-Il Sci Rep Article This study aimed to describe the clinical characteristics of age-related macular degeneration (AMD) eyes with both cuticular drusen (CD) and reticular pseudodrusen (RPD). Clinical records of patients diagnosed with CD or RPD with multimodal imaging was reviewed for patients diagnosed with both CD and RPD. The distribution patterns of CD (macular and diffuse type) and RPD (localized, intermediate, and diffuse type), presence of soft drusen, large drusen (> 200 µm), variant subretinal drusenoid deposits, and macular complications were investigated. Of the 220 eyes of 110 patients diagnosed with CD and 926 eyes of 463 patients diagnosed with RPD, 13 eyes of seven patients met the diagnostic criteria for both CD and RPD. The mean age at initial presentation was 71.4 ± 8.8 years and six patients were female. The mean subfoveal choroidal thickness was 143.8 ± 25.1 µm. The distribution of CD was of the macular type in all eyes. Distribution of RPD was localized in 11 eyes (84.6%) and intermediate in two eyes (15.4%). Soft drusen, large drusen, and variant subretinal drusenoid deposits were present in 13 (100%), 12 (92.3%) and, seven (53.8%) eyes, respectively. Macular neovascularization was observed in two eyes (15.4%). CD and RPD can coexist in eyes with AMD. Multimodal imaging should be used for AMD eyes with features suggestive of CD and RPD, considering the high likelihood of developing late AMD. Nature Publishing Group UK 2022-04-05 /pmc/articles/PMC8983695/ /pubmed/35383241 http://dx.doi.org/10.1038/s41598-022-09608-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yoon, Je Moon Shin, Dong Hoon Kong, Mingui Ham, Don-Il Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title | Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title_full | Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title_fullStr | Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title_full_unstemmed | Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title_short | Age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
title_sort | age-related macular degeneration eyes presenting with cuticular drusen and reticular pseudodrusen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983695/ https://www.ncbi.nlm.nih.gov/pubmed/35383241 http://dx.doi.org/10.1038/s41598-022-09608-9 |
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