Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5 (Cdk5) as a suppres...

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Detalles Bibliográficos
Autores principales: Ahmad, Mubashir, Krüger, Benjamin Thilo, Kroll, Torsten, Vettorazzi, Sabine, Dorn, Ann-Kristin, Mengele, Florian, Lee, Sooyeon, Nandi, Sayantan, Yilmaz, Dilay, Stolz, Miriam, Tangudu, Naveen Kumar, Vázquez, David Carro, Pachmayr, Johanna, Cirstea, Ion Cristian, Spasic, Maja Vujic, Ploubidou, Aspasia, Ignatius, Anita, Tuckermann, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983726/
https://www.ncbi.nlm.nih.gov/pubmed/35383146
http://dx.doi.org/10.1038/s41413-022-00195-z

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