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Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Trans-chromosomic (Tc) mice carrying mini-chromosomes with megabase-sized human immunoglobulin (Ig) loci have contributed to the development of fully human therapeutic monoclonal antibodies, but mitotic instability of human mini-chromosomes in mice may limit the efficiency of hybridoma production. H...

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Detalles Bibliográficos
Autores principales:	Satofuka, Hiroyuki, Abe, Satoshi, Moriwaki, Takashi, Okada, Akane, Kazuki, Kanako, Tanaka, Hiroshi, Yamazaki, Kyotaro, Hichiwa, Genki, Morimoto, Kayoko, Takayama, Haruka, Nakayama, Yuji, Hatano, Shinya, Yada, Yutaro, Murakami, Yasufumi, Baba, Yoshihiro, Oshimura, Mitsuo, Tomizuka, Kazuma, Kazuki, Yasuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983744/ https://www.ncbi.nlm.nih.gov/pubmed/35383174 http://dx.doi.org/10.1038/s41467-022-29421-2

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