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Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in three domains including emotional processing, cognitive processing, and psychomotor dimensions. However, the neural underpinnings underlying these clinical profiles are not well understood. Based on the reported...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983759/ https://www.ncbi.nlm.nih.gov/pubmed/35383150 http://dx.doi.org/10.1038/s41398-022-01917-x |
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author | Bi, Bo Che, Dongfang Bai, Yuyin |
author_facet | Bi, Bo Che, Dongfang Bai, Yuyin |
author_sort | Bi, Bo |
collection | PubMed |
description | Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in three domains including emotional processing, cognitive processing, and psychomotor dimensions. However, the neural underpinnings underlying these clinical profiles are not well understood. Based on the reported data, we hypothesized that (i) the core neuropathology in BD is damage in fronto-limbic network, which is associated with emotional dysfunction; (ii) changes in intrinsic brain network, such as sensorimotor network, salience network, default-mode network, central executive network are associated with impaired cognition function; and (iii) beyond the dopaminergic-driven basal ganglia-thalamo-cortical motor circuit modulated by other neurotransmitter systems, such as serotonin (subcortical–cortical modulation), the sensorimotor network and related motor function modulated by other non-motor networks such as the default-mode network are involved in psychomotor function. In this review, we propose a neurocircuit-based clinical characteristics and taxonomy to guide the treatment of BD. We draw on findings from neuropsychological and neuroimaging studies in BD and link variations in these clinical profiles to underlying neurocircuit dysfunctions. We consider pharmacological, psychotherapy, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions in BD. Finally, it is suggested that the methods of testing the neurocircuit-based taxonomy and important limitations to this approach should be considered in future. |
format | Online Article Text |
id | pubmed-8983759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89837592022-04-22 Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies Bi, Bo Che, Dongfang Bai, Yuyin Transl Psychiatry Review Article Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in three domains including emotional processing, cognitive processing, and psychomotor dimensions. However, the neural underpinnings underlying these clinical profiles are not well understood. Based on the reported data, we hypothesized that (i) the core neuropathology in BD is damage in fronto-limbic network, which is associated with emotional dysfunction; (ii) changes in intrinsic brain network, such as sensorimotor network, salience network, default-mode network, central executive network are associated with impaired cognition function; and (iii) beyond the dopaminergic-driven basal ganglia-thalamo-cortical motor circuit modulated by other neurotransmitter systems, such as serotonin (subcortical–cortical modulation), the sensorimotor network and related motor function modulated by other non-motor networks such as the default-mode network are involved in psychomotor function. In this review, we propose a neurocircuit-based clinical characteristics and taxonomy to guide the treatment of BD. We draw on findings from neuropsychological and neuroimaging studies in BD and link variations in these clinical profiles to underlying neurocircuit dysfunctions. We consider pharmacological, psychotherapy, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions in BD. Finally, it is suggested that the methods of testing the neurocircuit-based taxonomy and important limitations to this approach should be considered in future. Nature Publishing Group UK 2022-04-05 /pmc/articles/PMC8983759/ /pubmed/35383150 http://dx.doi.org/10.1038/s41398-022-01917-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Bi, Bo Che, Dongfang Bai, Yuyin Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title | Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title_full | Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title_fullStr | Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title_full_unstemmed | Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title_short | Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies |
title_sort | neural network of bipolar disorder: toward integration of neuroimaging and neurocircuit-based treatment strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983759/ https://www.ncbi.nlm.nih.gov/pubmed/35383150 http://dx.doi.org/10.1038/s41398-022-01917-x |
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